Impairment of T‐Helper Function by a Plasmodium berghei‐Derived Immunosuppressive Factor

EDWARD F. SROUR, MARIANGELA SEGRE, DIEGO SEGRE

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Mice injected with an immunosuppressive factor (ISF) extracted from Plasmodium berghei‐infected rat erythrocytes have a reduced antibody response to unrelated antigens. T‐cells from ISF‐treated mice failed to provide adequate help to naive, syngeneic B‐cells in the primary IgM response in vitro to sheep red blood cells and to dinitrophenylated keyhole limpet hemocyanin. The same T‐cells, however, were able to cooperate with memory B‐cells in the secondary IgG response. No other cellular deficit was delected in ISF‐treated mice; B‐cells and macrophages behaved normally, and there was no detectable excess of suppressor cells. The T‐cell impairment was not reflected in decreased production of interleukin 2, but was also shown by the diminished delayed type hyperaensitivity reaction to sheep red blood cells of ISF‐treated mice.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalThe Journal of Protozoology
Volume35
Issue number4
DOIs
StatePublished - Nov 1988
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology

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