Mice injected with an immunosuppressive factor (ISF) extracted from Plasmodium berghei‐infected rat erythrocytes have a reduced antibody response to unrelated antigens. T‐cells from ISF‐treated mice failed to provide adequate help to naive, syngeneic B‐cells in the primary IgM response in vitro to sheep red blood cells and to dinitrophenylated keyhole limpet hemocyanin. The same T‐cells, however, were able to cooperate with memory B‐cells in the secondary IgG response. No other cellular deficit was delected in ISF‐treated mice; B‐cells and macrophages behaved normally, and there was no detectable excess of suppressor cells. The T‐cell impairment was not reflected in decreased production of interleukin 2, but was also shown by the diminished delayed type hyperaensitivity reaction to sheep red blood cells of ISF‐treated mice.
|Original language||English (US)|
|Number of pages||6|
|Journal||The Journal of Protozoology|
|State||Published - Nov 1988|
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