Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

Z. Schwartz, C. H. Lohmann, J. Oefinger, Lynda Bonewald, D. D. Dean, B. D. Boyan

Research output: Contribution to journalReview article

226 Citations (Scopus)

Abstract

This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

Original languageEnglish (US)
Pages (from-to)38-48
Number of pages11
JournalAdvances in dental research
Volume13
StatePublished - 1999
Externally publishedYes

Fingerprint

Cell Differentiation
Osteoblasts
Transforming Growth Factor beta1
Osteocalcin
Differentiation Antigens
Osteosarcoma
Dinoprostone
Indomethacin
Prostaglandins
Alkaline Phosphatase
Cell Line
Growth

Cite this

Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage. / Schwartz, Z.; Lohmann, C. H.; Oefinger, J.; Bonewald, Lynda; Dean, D. D.; Boyan, B. D.

In: Advances in dental research, Vol. 13, 1999, p. 38-48.

Research output: Contribution to journalReview article

Schwartz, Z. ; Lohmann, C. H. ; Oefinger, J. ; Bonewald, Lynda ; Dean, D. D. ; Boyan, B. D. / Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage. In: Advances in dental research. 1999 ; Vol. 13. pp. 38-48.
@article{a4440c4643874e378d51eb033af10e16,
title = "Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.",
abstract = "This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.",
author = "Z. Schwartz and Lohmann, {C. H.} and J. Oefinger and Lynda Bonewald and Dean, {D. D.} and Boyan, {B. D.}",
year = "1999",
language = "English (US)",
volume = "13",
pages = "38--48",
journal = "Advances in dental research",
issn = "0895-9374",
publisher = "International Association for Dental Research",

}

TY - JOUR

T1 - Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage.

AU - Schwartz, Z.

AU - Lohmann, C. H.

AU - Oefinger, J.

AU - Bonewald, Lynda

AU - Dean, D. D.

AU - Boyan, B. D.

PY - 1999

Y1 - 1999

N2 - This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

AB - This paper reviews the role of surface roughness in the osteogenic response to implant materials. Cells in the osteoblast lineage respond to roughness in cell-maturation-specific ways, exhibiting surface-dependent morphologies and growth characteristics. MG63 cells, a human osteoblast-like osteosarcoma cell line, respond to increasing surface roughness with decreased proliferation and increased osteoblastic differentiation. Alkaline phosphatase activity and osteocalcin production are increased. Local factor production is also affected; production of both TGF-beta 1 and PGE2 is increased. On rougher surfaces, MG63 cells exhibit enhanced responsiveness to 1,25-(OH)2D3. Prostaglandins mediate the effects of surface roughness, since indomethacin prevents the increased expression of differentiation markers in these cells.

UR - http://www.scopus.com/inward/record.url?scp=0033140231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033140231&partnerID=8YFLogxK

M3 - Review article

VL - 13

SP - 38

EP - 48

JO - Advances in dental research

JF - Advances in dental research

SN - 0895-9374

ER -