Implementation of a distributed architecture for managing collection and dissemination of data for fetal alcohol spectrum disorders research

Andrew Arenson, Ludmila Bakhireva, Tina Chambers, Christina Deximo, Tatiana Foroud, Joseph Jacobson, Sandra Jacobson, Kenneth Lyons Jones, Sarah Mattson, Philip May, Elizabeth Moore, Kimberly Ogle, Edward Riley, Luther Robinson, Jeffrey Rogers, Ann Streissguth, Michel Tavares, Joseph Urbanski, Helen Yezerets, Craig A. Stewart

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We implemented a distributed system for management of data for an international collaboration studying Fetal Alcohol Spectrum Disorders (FASD). Subject privacy was protected, researchers without dependable Internet access were accommodated, and researchers' data were shared globally. Data dictionaries codified the nature of the data being integrated, data compliance was assured through multiple consistency checks, and recovery systems provided a secure, robust, persistent repository. The system enabled new types of science to be done, using distributed technologies that are expedient for current needs while taking useful steps towards integrating the system in a future grid-based cyberinfrastructure. The distributed architecture, verification steps, and data dictionaries suggest general strategies for researchers involved in collaborative studies, particularly where data must be de-identified before being shared. The system met both the collaboration's needs and the NIH Roadmap's goal of wide access to databases that are robust and adaptable to researchers' needs.

Original languageEnglish (US)
Title of host publicationDistributed, High-Performance and Grid Computing in Computational Biology International Workshop, GCCB 2006, Proceedings
PublisherSpringer Verlag
Pages33-44
Number of pages12
ISBN (Print)3540698418, 9783540698418
DOIs
StatePublished - 2007
Externally publishedYes
EventDistributed, High-Performance and Grid Computing in Computational Biology International Workshop, GCCB 2006 - Eilat, Israel
Duration: Jan 21 2007 → Jan 21 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4360 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

OtherDistributed, High-Performance and Grid Computing in Computational Biology International Workshop, GCCB 2006
CountryIsrael
CityEilat
Period1/21/07 → 1/21/07

Keywords

  • Data dictionary
  • Distributed computing
  • Fetal alcohol spectrum disorders
  • Repository

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

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    Arenson, A., Bakhireva, L., Chambers, T., Deximo, C., Foroud, T., Jacobson, J., Jacobson, S., Jones, K. L., Mattson, S., May, P., Moore, E., Ogle, K., Riley, E., Robinson, L., Rogers, J., Streissguth, A., Tavares, M., Urbanski, J., Yezerets, H., & Stewart, C. A. (2007). Implementation of a distributed architecture for managing collection and dissemination of data for fetal alcohol spectrum disorders research. In Distributed, High-Performance and Grid Computing in Computational Biology International Workshop, GCCB 2006, Proceedings (pp. 33-44). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4360 LNBI). Springer Verlag. https://doi.org/10.1007/978-3-540-69968-2_4