Implementation of a renal precision medicine program: Clinician attitudes and acceptance

Katherine M. Spiech, Purnima R. Tripathy, Alex M. Woodcock, Nehal A. Sheth, Kimberly S. Collins, Karthik Kannegolla, Arjun D. Sinha, Asif A. Sharfuddin, Victoria M. Pratt, Myda Khalid, David S. Hains, Sharon M. Moe, Todd C. Skaar, Ranjani N. Moorthi, Michael T. Eadon

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


A precision health initiative was implemented across a multi-hospital health system, wherein a panel of genetic variants was tested and utilized in the clinical care of chronic kidney disease (CKD) patients. Pharmacogenomic predictors of antihypertensive response and genomic predictors of CKD were provided to clinicians caring for nephrology patients. To assess clinician knowledge, attitudes, and willingness to act on genetic testing results, a Likert-scale survey was sent to and self-administered by these nephrology providers (N = 76). Most respondents agreed that utilizing pharmacogenomic-guided antihypertensive prescribing is valuable (4.0 ± 0.7 on a scale of 1 to 5, where 5 indicates strong agreement). However, the respondents also expressed reluctance to use genetic testing for CKD risk stratification due to a perceived lack of supporting evidence (3.2 ± 0.9). Exploratory sub-group analyses associated this reluctance with negative responses to both knowledge and attitude discipline questions, thus suggesting reduced exposure to and comfort with genetic information. Given the evolving nature of genomic implementation in clinical care, further education is warranted to help overcome these perception barriers.

Original languageEnglish (US)
Article number32
Issue number4
StatePublished - Apr 2020


  • APOL1
  • Chronic kidney disease (CKD)
  • Genetic testing
  • Hypertension (HTN)
  • Pharmacogenomics

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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