Implementation of guidelines in eosinophilic esophagitis at an academic pediatric practice

Brendan R. Harris, Emily Hon, Sandeep Gupta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Guidelines for eosinophilic esophagitis (EoE) require high-dose PPI (HD-PPI) trial to evaluate for PPI-responsive esophageal eosinophilia (PPI-REE) prior to EoE diagnosis and dedicated therapy. This involves a second esophagogastroduodenoscopy (EGD) to assess for PPI-REE. This study is to evaluate adherence to current guidelines in evaluation of PPI-REE and EoE. Retrospective review of new patients treated with HD-PPI after an index EGD showing >15 eos/hpf in esophageal biopsies. One hundred and eighty patients had an index EGD with esophageal eosinophilia of >15 eos/hpf. Of these, 97/180 (53.8%) received HD-PPI; remaining 83/180 were prescribed other interventions without a HD-PPI trial. Of the 180 patients, 143 (79.4%) patients returned for follow-up and of whom 96/143 (67.1%) underwent repeat EGD. Adherence to guidelines improves with time. Patients are vested in care.

Original languageEnglish (US)
JournalDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
Volume31
Issue number8
DOIs
StatePublished - Aug 1 2018
Externally publishedYes

Fingerprint

Eosinophilic Esophagitis
Digestive System Endoscopy
Eosinophilia
Guidelines
Pediatrics
Guideline Adherence
Biopsy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{9d0e350a73154553be77deaba387912c,
title = "Implementation of guidelines in eosinophilic esophagitis at an academic pediatric practice",
abstract = "Guidelines for eosinophilic esophagitis (EoE) require high-dose PPI (HD-PPI) trial to evaluate for PPI-responsive esophageal eosinophilia (PPI-REE) prior to EoE diagnosis and dedicated therapy. This involves a second esophagogastroduodenoscopy (EGD) to assess for PPI-REE. This study is to evaluate adherence to current guidelines in evaluation of PPI-REE and EoE. Retrospective review of new patients treated with HD-PPI after an index EGD showing >15 eos/hpf in esophageal biopsies. One hundred and eighty patients had an index EGD with esophageal eosinophilia of >15 eos/hpf. Of these, 97/180 (53.8{\%}) received HD-PPI; remaining 83/180 were prescribed other interventions without a HD-PPI trial. Of the 180 patients, 143 (79.4{\%}) patients returned for follow-up and of whom 96/143 (67.1{\%}) underwent repeat EGD. Adherence to guidelines improves with time. Patients are vested in care.",
author = "Harris, {Brendan R.} and Emily Hon and Sandeep Gupta",
year = "2018",
month = "8",
day = "1",
doi = "10.1093/dote/doy029",
language = "English (US)",
volume = "31",
journal = "Diseases of the Esophagus",
issn = "1120-8694",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Implementation of guidelines in eosinophilic esophagitis at an academic pediatric practice

AU - Harris, Brendan R.

AU - Hon, Emily

AU - Gupta, Sandeep

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Guidelines for eosinophilic esophagitis (EoE) require high-dose PPI (HD-PPI) trial to evaluate for PPI-responsive esophageal eosinophilia (PPI-REE) prior to EoE diagnosis and dedicated therapy. This involves a second esophagogastroduodenoscopy (EGD) to assess for PPI-REE. This study is to evaluate adherence to current guidelines in evaluation of PPI-REE and EoE. Retrospective review of new patients treated with HD-PPI after an index EGD showing >15 eos/hpf in esophageal biopsies. One hundred and eighty patients had an index EGD with esophageal eosinophilia of >15 eos/hpf. Of these, 97/180 (53.8%) received HD-PPI; remaining 83/180 were prescribed other interventions without a HD-PPI trial. Of the 180 patients, 143 (79.4%) patients returned for follow-up and of whom 96/143 (67.1%) underwent repeat EGD. Adherence to guidelines improves with time. Patients are vested in care.

AB - Guidelines for eosinophilic esophagitis (EoE) require high-dose PPI (HD-PPI) trial to evaluate for PPI-responsive esophageal eosinophilia (PPI-REE) prior to EoE diagnosis and dedicated therapy. This involves a second esophagogastroduodenoscopy (EGD) to assess for PPI-REE. This study is to evaluate adherence to current guidelines in evaluation of PPI-REE and EoE. Retrospective review of new patients treated with HD-PPI after an index EGD showing >15 eos/hpf in esophageal biopsies. One hundred and eighty patients had an index EGD with esophageal eosinophilia of >15 eos/hpf. Of these, 97/180 (53.8%) received HD-PPI; remaining 83/180 were prescribed other interventions without a HD-PPI trial. Of the 180 patients, 143 (79.4%) patients returned for follow-up and of whom 96/143 (67.1%) underwent repeat EGD. Adherence to guidelines improves with time. Patients are vested in care.

UR - http://www.scopus.com/inward/record.url?scp=85059893077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059893077&partnerID=8YFLogxK

U2 - 10.1093/dote/doy029

DO - 10.1093/dote/doy029

M3 - Article

C2 - 29757350

AN - SCOPUS:85059893077

VL - 31

JO - Diseases of the Esophagus

JF - Diseases of the Esophagus

SN - 1120-8694

IS - 8

ER -