Implementation of subjective cognitive decline criteria in research studies

José L. Molinuevo, Laura A. Rabin, Rebecca Amariglio, Rachel Buckley, Bruno Dubois, Kathryn A. Ellis, Michael Ewers, Harald Hampel, Stefan Klöppel, Lorena Rami, Barry Reisberg, Andrew Saykin, Sietske Sikkes, Colette M. Smart, Beth E. Snitz, Reisa Sperling, Wiesje M. van der Flier, Michael Wagner, Frank Jessen

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2016

Fingerprint

Research
Alzheimer Disease
Cognitive Dysfunction
Health Services Needs and Demand
Demography

Keywords

  • Alzheimer's disease
  • Harmonization
  • Operationalization
  • Preclinical
  • SCD-I
  • Subjective cognitive decline (SDC)

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Molinuevo, J. L., Rabin, L. A., Amariglio, R., Buckley, R., Dubois, B., Ellis, K. A., ... Jessen, F. (Accepted/In press). Implementation of subjective cognitive decline criteria in research studies. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.09.012

Implementation of subjective cognitive decline criteria in research studies. / Molinuevo, José L.; Rabin, Laura A.; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A.; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew; Sikkes, Sietske; Smart, Colette M.; Snitz, Beth E.; Sperling, Reisa; van der Flier, Wiesje M.; Wagner, Michael; Jessen, Frank.

In: Alzheimer's and Dementia, 2016.

Research output: Contribution to journalArticle

Molinuevo, JL, Rabin, LA, Amariglio, R, Buckley, R, Dubois, B, Ellis, KA, Ewers, M, Hampel, H, Klöppel, S, Rami, L, Reisberg, B, Saykin, A, Sikkes, S, Smart, CM, Snitz, BE, Sperling, R, van der Flier, WM, Wagner, M & Jessen, F 2016, 'Implementation of subjective cognitive decline criteria in research studies', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2016.09.012
Molinuevo, José L. ; Rabin, Laura A. ; Amariglio, Rebecca ; Buckley, Rachel ; Dubois, Bruno ; Ellis, Kathryn A. ; Ewers, Michael ; Hampel, Harald ; Klöppel, Stefan ; Rami, Lorena ; Reisberg, Barry ; Saykin, Andrew ; Sikkes, Sietske ; Smart, Colette M. ; Snitz, Beth E. ; Sperling, Reisa ; van der Flier, Wiesje M. ; Wagner, Michael ; Jessen, Frank. / Implementation of subjective cognitive decline criteria in research studies. In: Alzheimer's and Dementia. 2016.
@article{32852042ea98495baf8aeb8d7fb263d2,
title = "Implementation of subjective cognitive decline criteria in research studies",
abstract = "Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.",
keywords = "Alzheimer's disease, Harmonization, Operationalization, Preclinical, SCD-I, Subjective cognitive decline (SDC)",
author = "Molinuevo, {Jos{\'e} L.} and Rabin, {Laura A.} and Rebecca Amariglio and Rachel Buckley and Bruno Dubois and Ellis, {Kathryn A.} and Michael Ewers and Harald Hampel and Stefan Kl{\"o}ppel and Lorena Rami and Barry Reisberg and Andrew Saykin and Sietske Sikkes and Smart, {Colette M.} and Snitz, {Beth E.} and Reisa Sperling and {van der Flier}, {Wiesje M.} and Michael Wagner and Frank Jessen",
year = "2016",
doi = "10.1016/j.jalz.2016.09.012",
language = "English (US)",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Implementation of subjective cognitive decline criteria in research studies

AU - Molinuevo, José L.

AU - Rabin, Laura A.

AU - Amariglio, Rebecca

AU - Buckley, Rachel

AU - Dubois, Bruno

AU - Ellis, Kathryn A.

AU - Ewers, Michael

AU - Hampel, Harald

AU - Klöppel, Stefan

AU - Rami, Lorena

AU - Reisberg, Barry

AU - Saykin, Andrew

AU - Sikkes, Sietske

AU - Smart, Colette M.

AU - Snitz, Beth E.

AU - Sperling, Reisa

AU - van der Flier, Wiesje M.

AU - Wagner, Michael

AU - Jessen, Frank

PY - 2016

Y1 - 2016

N2 - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

AB - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.

KW - Alzheimer's disease

KW - Harmonization

KW - Operationalization

KW - Preclinical

KW - SCD-I

KW - Subjective cognitive decline (SDC)

UR - http://www.scopus.com/inward/record.url?scp=85006908624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006908624&partnerID=8YFLogxK

U2 - 10.1016/j.jalz.2016.09.012

DO - 10.1016/j.jalz.2016.09.012

M3 - Article

C2 - 27825022

AN - SCOPUS:85006908624

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

SN - 1552-5260

ER -