Abstract
Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
| Original language | English (US) |
|---|---|
| Journal | Alzheimer's and Dementia |
| DOIs | |
| State | Accepted/In press - 2016 |
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Keywords
- Alzheimer's disease
- Harmonization
- Operationalization
- Preclinical
- SCD-I
- Subjective cognitive decline (SDC)
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Geriatrics and Gerontology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
Implementation of subjective cognitive decline criteria in research studies. / Molinuevo, José L.; Rabin, Laura A.; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A.; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew; Sikkes, Sietske; Smart, Colette M.; Snitz, Beth E.; Sperling, Reisa; van der Flier, Wiesje M.; Wagner, Michael; Jessen, Frank.
In: Alzheimer's and Dementia, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Implementation of subjective cognitive decline criteria in research studies
AU - Molinuevo, José L.
AU - Rabin, Laura A.
AU - Amariglio, Rebecca
AU - Buckley, Rachel
AU - Dubois, Bruno
AU - Ellis, Kathryn A.
AU - Ewers, Michael
AU - Hampel, Harald
AU - Klöppel, Stefan
AU - Rami, Lorena
AU - Reisberg, Barry
AU - Saykin, Andrew
AU - Sikkes, Sietske
AU - Smart, Colette M.
AU - Snitz, Beth E.
AU - Sperling, Reisa
AU - van der Flier, Wiesje M.
AU - Wagner, Michael
AU - Jessen, Frank
PY - 2016
Y1 - 2016
N2 - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
AB - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
KW - Alzheimer's disease
KW - Harmonization
KW - Operationalization
KW - Preclinical
KW - SCD-I
KW - Subjective cognitive decline (SDC)
UR - http://www.scopus.com/inward/record.url?scp=85006908624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006908624&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2016.09.012
DO - 10.1016/j.jalz.2016.09.012
M3 - Article
C2 - 27825022
AN - SCOPUS:85006908624
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -