Abstract
Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
Original language | English (US) |
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Journal | Alzheimer's and Dementia |
DOIs | |
State | Accepted/In press - 2016 |
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Keywords
- Alzheimer's disease
- Harmonization
- Operationalization
- Preclinical
- SCD-I
- Subjective cognitive decline (SDC)
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Geriatrics and Gerontology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
Implementation of subjective cognitive decline criteria in research studies. / Molinuevo, José L.; Rabin, Laura A.; Amariglio, Rebecca; Buckley, Rachel; Dubois, Bruno; Ellis, Kathryn A.; Ewers, Michael; Hampel, Harald; Klöppel, Stefan; Rami, Lorena; Reisberg, Barry; Saykin, Andrew; Sikkes, Sietske; Smart, Colette M.; Snitz, Beth E.; Sperling, Reisa; van der Flier, Wiesje M.; Wagner, Michael; Jessen, Frank.
In: Alzheimer's and Dementia, 2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Implementation of subjective cognitive decline criteria in research studies
AU - Molinuevo, José L.
AU - Rabin, Laura A.
AU - Amariglio, Rebecca
AU - Buckley, Rachel
AU - Dubois, Bruno
AU - Ellis, Kathryn A.
AU - Ewers, Michael
AU - Hampel, Harald
AU - Klöppel, Stefan
AU - Rami, Lorena
AU - Reisberg, Barry
AU - Saykin, Andrew
AU - Sikkes, Sietske
AU - Smart, Colette M.
AU - Snitz, Beth E.
AU - Sperling, Reisa
AU - van der Flier, Wiesje M.
AU - Wagner, Michael
AU - Jessen, Frank
PY - 2016
Y1 - 2016
N2 - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
AB - Introduction: Subjective cognitive decline (SCD) manifesting before clinical impairment could serve as a target population for early intervention trials in Alzheimer's disease (AD). A working group, the Subjective Cognitive Decline Initiative (SCD-I), published SCD research criteria in the context of preclinical AD. To successfully apply them, a number of issues regarding assessment and implementation of SCD needed to be addressed. Methods: Members of the SCD-I met to identify and agree on topics relevant to SCD criteria operationalization in research settings. Initial ideas and recommendations were discussed with other SCD-I working group members and modified accordingly. Results: Topics included SCD inclusion and exclusion criteria, together with the informant's role in defining SCD presence and the impact of demographic factors. Discussion: Recommendations for the operationalization of SCD in differing research settings, with the aim of harmonization of SCD measurement across studies are proposed, to enhance comparability and generalizability across studies.
KW - Alzheimer's disease
KW - Harmonization
KW - Operationalization
KW - Preclinical
KW - SCD-I
KW - Subjective cognitive decline (SDC)
UR - http://www.scopus.com/inward/record.url?scp=85006908624&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006908624&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2016.09.012
DO - 10.1016/j.jalz.2016.09.012
M3 - Article
C2 - 27825022
AN - SCOPUS:85006908624
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -