Implications of cancer stem cells in the treatment of cancer

Chong Xian Pan, Wei Zhu, Liang Cheng

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Identification of cancer stem cells (CSCs) in both hematological and solid malignancies suggests that CSCs may be a common phenomenon for most malignancies. Similarly to normal stem cells, CSCs can self-renew and differentiate into progeny cancer cells. Almost all current therapy against cancer targets differentiated cancer cells. CSCs are more resistant to therapy secondary to quiescence, increased expression of antiapoptotic proteins and drug efflux transporters. In this article, we review the current status of CSC research and propose the targeting of CSC cell-surface molecules, signal transduction pathways, the stem cell niche, stem cell differentiation and drug resistance.

Original languageEnglish (US)
Pages (from-to)723-731
Number of pages9
JournalFuture Oncology
Volume2
Issue number6
DOIs
StatePublished - Dec 1 2006

Keywords

  • Cancer stem cell
  • Differentiation
  • Drug resistance
  • Stem cell
  • Stem cell niche
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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