Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types

Xuan Ou, Heather A. O'Leary, Hal E. Broxmeyer

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Dipeptidylpeptidase (DPP) 4 has the potential to truncate proteins with a penultimate alanine, proline, or other selective amino acids at the N -terminus. DPP4 truncation of certain chemokines, colony-stimulating factors, and interleukins have recently been linked to regulation of hematopoietic stem/progenitor cells,more mature blood cells, and other cell types. We believe that the potential role of DPP4 in modification of many regulatory proteins, and their subsequent effects on numerous stem/progenitor and other cell-type functions has not been adequately appreciated. This review addresses the potential implications of the modifying effects of DPP4 on a large number of cytokines and other growth-regulating factors with either proven or putative DPP4 truncation sites on hematopoietic cells, and subsequent effects of DPP4-truncated proteins on multiple aspects of steady-state and stressed hematopoiesis, including stem/progenitor cell, and more mature cell, function.

Original languageEnglish (US)
Pages (from-to)161-169
Number of pages9
JournalBlood
Volume122
Issue number2
DOIs
StatePublished - Jan 1 2013

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Stem Cells
Hematopoietic Stem Cells
Stem cells
Colony-Stimulating Factors
Proteins
Interleukins
Hematopoiesis
Chemokines
Proline
Alanine
Blood Cells
Intercellular Signaling Peptides and Proteins
Blood
Cells
Cytokines
Amino Acids

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Implications of DPP4 modification of proteins that regulate stem/progenitor and more mature cell types. / Ou, Xuan; O'Leary, Heather A.; Broxmeyer, Hal E.

In: Blood, Vol. 122, No. 2, 01.01.2013, p. 161-169.

Research output: Contribution to journalReview article

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