Importance of delta opioid receptors in maintaining high alcohol drinking

Janice Froehlich, M. Zweifel, J. Harts, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking.

Original languageEnglish
Pages (from-to)467-472
Number of pages6
JournalPsychopharmacology
Volume103
Issue number4
DOIs
StatePublished - Apr 1991

Fingerprint

delta Opioid Receptor
Alcohol Drinking
Narcotic Antagonists
Alcohols
Naloxone
Neprilysin
Enkephalins
Opioid Receptors
Occupations
Drinking
Maintenance

Keywords

  • Delta opioid receptor antagonist
  • Enkephalinase inhibitors
  • Enkephalins
  • Genetic selection
  • Opioids
  • Voluntary alcohol consumption

ASJC Scopus subject areas

  • Pharmacology

Cite this

Importance of delta opioid receptors in maintaining high alcohol drinking. / Froehlich, Janice; Zweifel, M.; Harts, J.; Lumeng, L.; Li, T. K.

In: Psychopharmacology, Vol. 103, No. 4, 04.1991, p. 467-472.

Research output: Contribution to journalArticle

Froehlich, Janice ; Zweifel, M. ; Harts, J. ; Lumeng, L. ; Li, T. K. / Importance of delta opioid receptors in maintaining high alcohol drinking. In: Psychopharmacology. 1991 ; Vol. 103, No. 4. pp. 467-472.
@article{dc7c52986add482cb0df703f7c56b330,
title = "Importance of delta opioid receptors in maintaining high alcohol drinking",
abstract = "We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking.",
keywords = "Delta opioid receptor antagonist, Enkephalinase inhibitors, Enkephalins, Genetic selection, Opioids, Voluntary alcohol consumption",
author = "Janice Froehlich and M. Zweifel and J. Harts and L. Lumeng and Li, {T. K.}",
year = "1991",
month = "4",
doi = "10.1007/BF02244246",
language = "English",
volume = "103",
pages = "467--472",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Importance of delta opioid receptors in maintaining high alcohol drinking

AU - Froehlich, Janice

AU - Zweifel, M.

AU - Harts, J.

AU - Lumeng, L.

AU - Li, T. K.

PY - 1991/4

Y1 - 1991/4

N2 - We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking.

AB - We have previously reported that naloxone, a nonspecific opioid receptor antagonist, suppresses alcohol but not water consumption by male rats that have been genetically selected for high voluntary alcohol drinking. However, the identity of the specific opioid receptor subtype that may mediate alcohol drinking is not known. This paper reports that a selective delta opioid receptor antagonist is as effective as naloxone in suppressing alcohol consumption and that an enkephalinase inhibitor, which potentiates the action of endogenous enkephalins, increases alcohol intake. These results suggest that alcohol-induced activation of the endogenous enkephalinergic system, and occupation of delta opioid receptors, are involved in the maintenance of continued alcohol drinking.

KW - Delta opioid receptor antagonist

KW - Enkephalinase inhibitors

KW - Enkephalins

KW - Genetic selection

KW - Opioids

KW - Voluntary alcohol consumption

UR - http://www.scopus.com/inward/record.url?scp=0026027048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026027048&partnerID=8YFLogxK

U2 - 10.1007/BF02244246

DO - 10.1007/BF02244246

M3 - Article

VL - 103

SP - 467

EP - 472

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 4

ER -