Improved chemotherapy in disseminated testicular cancer

Lawrence Einhorn, J. P. Donohue

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Abstract

Two combination chemotherapy regimens for disseminated testicular cancer are described. The present regimen of platinum vinblastine and bleomycin has been highly successful, producing 16 complete (80 per cent) and 4 partial (20 per cent) remissions. Furthermore, 2 patients have been rendered free of disease by the surgical removal of residual disease, making the effective complete remission rate in these 20 patients 90 per cent. Of these patients 16 are alive and 14 are free of disease for more than 8 to more than 20 months. Destpite the significant toxicity during the first 12 weeks of this therapeutic regimen it usually was manageable and maintenance therapy produced minimal toxicity. We believe that this regimen is a major advance in the management of patients with disseminated testicular cancer.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalJournal of Urology
Volume117
Issue number1
StatePublished - 1977

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Testicular Neoplasms
Drug Therapy
Vinblastine
Bleomycin
Combination Drug Therapy
Platinum
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Improved chemotherapy in disseminated testicular cancer. / Einhorn, Lawrence; Donohue, J. P.

In: Journal of Urology, Vol. 117, No. 1, 1977, p. 65-69.

Research output: Contribution to journalArticle

Einhorn, Lawrence ; Donohue, J. P. / Improved chemotherapy in disseminated testicular cancer. In: Journal of Urology. 1977 ; Vol. 117, No. 1. pp. 65-69.
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