Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes

Paris Roach, T. Strack, V. Arora, Z. Zhao, Eli Lilly

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 ± 0.32 vs 10.29 ± 0.41, p1c was lower for LP/NPL at endpoint (7.54 ± 0.11% vs 7.92 ± 0.10%, p=0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalInternational Journal of Clinical Practice
Volume55
Issue number3
StatePublished - 2001
Externally publishedYes

Fingerprint

Insulin Lispro
Protamines
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Suspensions
Hypoglycemia
Insulin, Regular, Human
Insulin Antibodies
Breakfast
Meals
Blood Glucose
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes",
abstract = "A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 ± 0.32 vs 10.29 ± 0.41, p1c was lower for LP/NPL at endpoint (7.54 ± 0.11{\%} vs 7.92 ± 0.10{\%}, p=0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.",
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T1 - Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes

AU - Roach, Paris

AU - Strack, T.

AU - Arora, V.

AU - Zhao, Z.

AU - Lilly, Eli

PY - 2001

Y1 - 2001

N2 - A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 ± 0.32 vs 10.29 ± 0.41, p1c was lower for LP/NPL at endpoint (7.54 ± 0.11% vs 7.92 ± 0.10%, p=0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.

AB - A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 ± 0.32 vs 10.29 ± 0.41, p1c was lower for LP/NPL at endpoint (7.54 ± 0.11% vs 7.92 ± 0.10%, p=0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.

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