Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes

P. Roach, T. Strack, V. Arora, Z. Zhao, Eli Lilly

Research output: Contribution to journalArticle

26 Scopus citations


A total of 166 patients (102 type 1, 64 type 2) were randomised to insulin lispro (LP) combined with insulin lispro protamine suspension (NPL), an intermediate-acting formulation of LP, or to regular human insulin (HR) combined with human NPH insulin (NPH) in this open-label, parallel study. Insulin doses were similar at endpoint. Blood glucose (BG) measurements (before and two hours after meals, bedtime, 3 a.m.)(mmol/l) were lower with LP/NPL two hours after breakfast (8.84 ± 0.32 vs 10.29 ± 0.41, p<0.001), before lunch (6.21 ± 0.20 vs 7.10 ± 0.31, p=0.016), two hours after the evening meal (10.18 ± 0.36 vs 7.86 ± 0.28, p<0.0.001), and at bedtime (7.85 ± 0.28 vs 9.43 ± 0.40, p=001). HbA 1c was lower for LP/NPL at endpoint (7.54 ± 0.11% vs 7.92 ± 0.10%, p=0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalInternational Journal of Clinical Practice
Issue number3
StatePublished - May 12 2001


ASJC Scopus subject areas

  • Medicine(all)

Cite this