Improved outcome for children with hepatoblastoma

M. D. Stringer, S. Hennayake, E. R. Howard, L. Spitz, E. A. Shafford, G. Mieli-Vergani, Romil Saxena, M. Malone, C. Dicks-Mireaux, J. Karani, A. P. Mowat, J. Pritchard

Research output: Contribution to journalArticle

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Abstract

Between 1981 and 1993, 41 children were treated for hepatoblastoma. Clinical, radiological and pathological data were reviewed retrospectively, focusing on surgical aspects of treatment and outcome. Fourteen children underwent primary resection of the hepatic tumour. One infant with severe congenital anomalies received only palliative treatment. Of 26 with irresectable disease, pulsed cytotoxic chemotherapy (cisplatin and doxorubicin) enabled subsequent surgical excision in 22 and one child with persistent extensive intrahepatic disease was successfully treated by liver transplantation. Thus, with a policy of selective preoperative chemotherapy, 90 per cent of hepatoblastomas were resectable. There were no perioperative deaths from haemorrhage but one child died from an intraoperative tumour embolus. A total of 28 survivors, 27 of whom are disease-free, were followed for a median of 5 years. The cumulative probability of survival in patients treated with intent to cure was 67 per cent. Analysis of survival data suggested a favourable outcome for those with a pure fetal histological tumour subtype. These results demonstrate significant progress in the treatment of hepatoblastoma.

Original languageEnglish (US)
Pages (from-to)386-391
Number of pages6
JournalBritish Journal of Surgery
Volume82
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

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Hepatoblastoma
Drug Therapy
Neoplasms
Survival Analysis
Embolism
Palliative Care
Liver Transplantation
Doxorubicin
Cisplatin
Survivors
Hemorrhage
Survival
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Stringer, M. D., Hennayake, S., Howard, E. R., Spitz, L., Shafford, E. A., Mieli-Vergani, G., ... Pritchard, J. (1995). Improved outcome for children with hepatoblastoma. British Journal of Surgery, 82(3), 386-391. https://doi.org/10.1002/bjs.1800820334

Improved outcome for children with hepatoblastoma. / Stringer, M. D.; Hennayake, S.; Howard, E. R.; Spitz, L.; Shafford, E. A.; Mieli-Vergani, G.; Saxena, Romil; Malone, M.; Dicks-Mireaux, C.; Karani, J.; Mowat, A. P.; Pritchard, J.

In: British Journal of Surgery, Vol. 82, No. 3, 1995, p. 386-391.

Research output: Contribution to journalArticle

Stringer, MD, Hennayake, S, Howard, ER, Spitz, L, Shafford, EA, Mieli-Vergani, G, Saxena, R, Malone, M, Dicks-Mireaux, C, Karani, J, Mowat, AP & Pritchard, J 1995, 'Improved outcome for children with hepatoblastoma', British Journal of Surgery, vol. 82, no. 3, pp. 386-391. https://doi.org/10.1002/bjs.1800820334
Stringer MD, Hennayake S, Howard ER, Spitz L, Shafford EA, Mieli-Vergani G et al. Improved outcome for children with hepatoblastoma. British Journal of Surgery. 1995;82(3):386-391. https://doi.org/10.1002/bjs.1800820334
Stringer, M. D. ; Hennayake, S. ; Howard, E. R. ; Spitz, L. ; Shafford, E. A. ; Mieli-Vergani, G. ; Saxena, Romil ; Malone, M. ; Dicks-Mireaux, C. ; Karani, J. ; Mowat, A. P. ; Pritchard, J. / Improved outcome for children with hepatoblastoma. In: British Journal of Surgery. 1995 ; Vol. 82, No. 3. pp. 386-391.
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