Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point dixon for dynamic contrast-enhanced magnetic resonance imaging

Yuan Le, Brian Dale, Fatih Akisik, Karen Koons, Chen Lin

Research output: Contribution to journalArticle

5 Scopus citations


Purpose To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI. Methods T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction. Results T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, Ktrans, and incremental area under the curve, but not Ve (P = 0.1). Conclusion Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present.

Original languageEnglish (US)
Pages (from-to)1677-1684
Number of pages8
JournalMagnetic Resonance in Medicine
Issue number4
StatePublished - Apr 1 2016



  • Dixon
  • fat suppression
  • variable flip angle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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