Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point dixon for dynamic contrast-enhanced magnetic resonance imaging

Yuan Le, Brian Dale, Fatih Akisik, Karen Koons, Chen Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI. Methods T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction. Results T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, Ktrans, and incremental area under the curve, but not Ve (P = 0.1). Conclusion Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present.

Original languageEnglish (US)
Pages (from-to)1677-1684
Number of pages8
JournalMagnetic Resonance in Medicine
Volume75
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Pharmacokinetics
Fats
Magnetic Resonance Imaging
Water
Gadolinium
Liver
Reference Values
Emulsions
Area Under Curve

Keywords

  • DCE-MRI
  • Dixon
  • fat suppression
  • variable flip angle

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{2209be9e2e724870b937f47719107f1c,
title = "Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point dixon for dynamic contrast-enhanced magnetic resonance imaging",
abstract = "Purpose To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI. Methods T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction. Results T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, Ktrans, and incremental area under the curve, but not Ve (P = 0.1). Conclusion Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present.",
keywords = "DCE-MRI, Dixon, fat suppression, variable flip angle",
author = "Yuan Le and Brian Dale and Fatih Akisik and Karen Koons and Chen Lin",
year = "2016",
month = "4",
day = "1",
doi = "10.1002/mrm.25639",
language = "English (US)",
volume = "75",
pages = "1677--1684",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Improved T1, contrast concentration, and pharmacokinetic parameter quantification in the presence of fat with two-point dixon for dynamic contrast-enhanced magnetic resonance imaging

AU - Le, Yuan

AU - Dale, Brian

AU - Akisik, Fatih

AU - Koons, Karen

AU - Lin, Chen

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Purpose To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI. Methods T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction. Results T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, Ktrans, and incremental area under the curve, but not Ve (P = 0.1). Conclusion Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present.

AB - Purpose To evaluate the impact of fat and fat-suppression on the quantification of T1, gadolinium concentration, and pharmacokinetic parameters in DCE-MRI. Methods T1 values were measured in fat-free phantoms using variable flip angle with no fat suppression, quick or interleaved fat saturation (QFS), or two-point Dixon and were compared with reference values measured with inversion recovery-prepared turbo spin echo. Relaxivity of gadolinium-benzyloxypropionictetraacetate (Gd-BOPTA) was measured in emulsions of Gd-BOPTA solution and fat using Dixon in-phase and water-only images. Liver T1 and pharmacokinetic parameters of 15 patients were calculated from Dixon in-phase and water-only images and were correlated with liver fat signal fraction. Results T1 values measured using Dixon water-only and non-fat-suppressed images matched the reference values; while T1 values measured using QFS showed large deviations. Relaxivities and Gd measured in the Dixon water-only images were less affected by the fat than those measured in the in-phase images. The correlation between liver fat fraction and the differences in measured pharmacokinetic parameters using Dixon in-phase and water-only images were significant (P < 0.05) for T1, Ktrans, and incremental area under the curve, but not Ve (P = 0.1). Conclusion Dixon water-only images provided more reliable estimation of T1, Gd, and pharmacokinetic parameters when fat was present.

KW - DCE-MRI

KW - Dixon

KW - fat suppression

KW - variable flip angle

UR - http://www.scopus.com/inward/record.url?scp=84930016821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930016821&partnerID=8YFLogxK

U2 - 10.1002/mrm.25639

DO - 10.1002/mrm.25639

M3 - Article

C2 - 25988338

AN - SCOPUS:84930016821

VL - 75

SP - 1677

EP - 1684

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 4

ER -