Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: A pilot study

Samir K. Gupta, Raymond M. Johnson, Chandan Saha, Kieren J. Mather, Martha L. Greenwald, Jeffrey S. Waltz, Jalees Rehman, Michael P. Dubé

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We hypothesized that heightened systemic inflammation contributes to the increased rate of cardiovascular events in HIV-infected patients not receiving combination antiretroviral therapy. We performed a pilot trial to assess the effects of the nuclear factor-κB inhibitor salsalate on flow-mediated dilation of the brachial artery, a measure of endothelial function. Flow-mediated dilation significantly improved after 8 weeks of salsalate. However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)653-655
Number of pages3
JournalAIDS
Volume22
Issue number5
DOIs
StatePublished - Mar 1 2008

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Dilatation
Anti-Inflammatory Agents
HIV
Inflammation
Brachial Artery
Cardiovascular Diseases
Research
salicylsalicylic acid
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate : A pilot study. / Gupta, Samir K.; Johnson, Raymond M.; Saha, Chandan; Mather, Kieren J.; Greenwald, Martha L.; Waltz, Jeffrey S.; Rehman, Jalees; Dubé, Michael P.

In: AIDS, Vol. 22, No. 5, 01.03.2008, p. 653-655.

Research output: Contribution to journalArticle

Gupta, Samir K. ; Johnson, Raymond M. ; Saha, Chandan ; Mather, Kieren J. ; Greenwald, Martha L. ; Waltz, Jeffrey S. ; Rehman, Jalees ; Dubé, Michael P. / Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate : A pilot study. In: AIDS. 2008 ; Vol. 22, No. 5. pp. 653-655.
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