Improvement of paraneoplastic opsoclonus-myoclonus after protein a column therapy

Mathias Nitschke, Fred Hochberg, Edward Dropcho

Research output: Contribution to journalLetter

30 Scopus citations


To the Editor: Some patients with cancer have a paraneoplastic syndrome of opsoclonus-myoclonus (dancing eyes-dancing feet), which may be caused by antibodies directed against antigens shared by tumor and cerebellar cells.1,2 We describe a patient with lung cancer who had opsoclonus-myoclonus associated with a neuronal antibody and in whom the condition improved after immunoadsorption therapy. A 48-year-old man with small-cell lung cancer had chaotic, omnidirectional, synchronous eye movements along with spontaneous jerks of the extremities, palate, and face. The movement disorder prevented him from walking, writing, and eating and did not improve with corticosteroid therapy. The patient's cerebellar function.  . .

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jan 19 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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