Improvements in the diagnosis of acute kidney injury.

Vyacheslav Y. Melnikov, Bruce Molitoris

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Acute kidney injury (AKI) represents a wide range of heterogeneous clinical conditions with a high mortality rate. Despite improvements in our understanding of the disease processes, mortality has only marginally improved and remains unacceptably high. An additional consequence of AKI is the marked acceleration of pre-existing chronic kidney disease to end-stage renal disease. A major limitation in improving outcomes of AKI has been the lack of common standards for diagnosis and severity stratification. Serum creatinine is a late marker of kidney dysfunction and injury. Presently, no available commercial test offers diagnosis, nor the ability to stratify patients by severity of injury, early in the course of disease when therapy may be beneficial. The Acute Dialysis Quality Initiative (ADQI) group proposed a standard definition and classification system for the syndrome of acute renal failure. Based on data that even small changes of serum creatinine result in increased mortality, the Acute Kidney Injury Network (AKIN) has recently proposed modified criteria. Both staging systems emphasize changes in serum creatinine and urine output. There is also potential that a number of serum and urine bio-markers developed in preclinical studies and currently being investigated and validated, will enable the early diagnosis of AKI.

Original languageEnglish
Pages (from-to)537-544
Number of pages8
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Volume19
Issue number4
StatePublished - Jul 2008
Externally publishedYes

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Acute Kidney Injury
Creatinine
Serum
Mortality
Urine
Wounds and Injuries
Chronic Renal Insufficiency
Chronic Kidney Failure
Early Diagnosis
Dialysis
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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