Improving graft survival for patients undergoing liver transplantation

Rolland C. Dickson, Surakit Pungpapong, Andrew P. Keaveny, C. Burcin Taner, Marwan Ghabril, Jaime Aranda-Michel, Raj Satyanarayana, Hugo Bonatti, David J. Kramer, Justin H. Nguyen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Liver transplant (LT) outcomes are reported to be improving in non-HCV recipients but not for those infected with HCV. Our aim was to evaluate graft survival and predictors of outcome in HCV and non-HCV patients before and after 2003. Patients with primary LT between February 1, 1998, and December 31, 2005, were included. Patients were divided into Era 1 (1998-2002) and Era 2 (2003-2005) with follow-up through May 31, 2009. Graft survival was compared for HCV, non-HCV, and all patients. There was significant improvement in graft survival in Era 2 for HCV patients. Graft survival in Era 2 of HCV patients was equivalent to non-HCV patients. The most significant improvement between eras was in outcomes of grafts from donors ≥60yr with three-yr graft survival 58.6 (51.3-65.9) vs. 75.4 (68.9-81.9), p=0.002. The use of donors ≥60 did not change between eras: 31% vs. 34%; however, utilization in HCV recipients decreased from 36% to 3% (p<0.001). In conclusion, graft survival of HCV patients has improved significantly since 2003 and was comparable to non-HCV patients up to threeyr. The change in management of donor organs into HCV and non-HCV patients likely contributed to this outcome.

Original languageEnglish
JournalClinical Transplantation
Volume25
Issue number3
DOIs
StatePublished - May 2011

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Graft Survival
Liver Transplantation
Tissue Donors
Transplants
Liver

Keywords

  • Hepatitis C
  • Liver transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this

Dickson, R. C., Pungpapong, S., Keaveny, A. P., Taner, C. B., Ghabril, M., Aranda-Michel, J., ... Nguyen, J. H. (2011). Improving graft survival for patients undergoing liver transplantation. Clinical Transplantation, 25(3). https://doi.org/10.1111/j.1399-0012.2011.01428.x

Improving graft survival for patients undergoing liver transplantation. / Dickson, Rolland C.; Pungpapong, Surakit; Keaveny, Andrew P.; Taner, C. Burcin; Ghabril, Marwan; Aranda-Michel, Jaime; Satyanarayana, Raj; Bonatti, Hugo; Kramer, David J.; Nguyen, Justin H.

In: Clinical Transplantation, Vol. 25, No. 3, 05.2011.

Research output: Contribution to journalArticle

Dickson, RC, Pungpapong, S, Keaveny, AP, Taner, CB, Ghabril, M, Aranda-Michel, J, Satyanarayana, R, Bonatti, H, Kramer, DJ & Nguyen, JH 2011, 'Improving graft survival for patients undergoing liver transplantation', Clinical Transplantation, vol. 25, no. 3. https://doi.org/10.1111/j.1399-0012.2011.01428.x
Dickson, Rolland C. ; Pungpapong, Surakit ; Keaveny, Andrew P. ; Taner, C. Burcin ; Ghabril, Marwan ; Aranda-Michel, Jaime ; Satyanarayana, Raj ; Bonatti, Hugo ; Kramer, David J. ; Nguyen, Justin H. / Improving graft survival for patients undergoing liver transplantation. In: Clinical Transplantation. 2011 ; Vol. 25, No. 3.
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