Improving graft survival for patients undergoing liver transplantation

Rolland C. Dickson, Surakit Pungpapong, Andrew P. Keaveny, C. Burcin Taner, Marwan Ghabril, Jaime Aranda-Michel, Raj Satyanarayana, Hugo Bonatti, David J. Kramer, Justin H. Nguyen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Liver transplant (LT) outcomes are reported to be improving in non-HCV recipients but not for those infected with HCV. Our aim was to evaluate graft survival and predictors of outcome in HCV and non-HCV patients before and after 2003. Patients with primary LT between February 1, 1998, and December 31, 2005, were included. Patients were divided into Era 1 (1998-2002) and Era 2 (2003-2005) with follow-up through May 31, 2009. Graft survival was compared for HCV, non-HCV, and all patients. There was significant improvement in graft survival in Era 2 for HCV patients. Graft survival in Era 2 of HCV patients was equivalent to non-HCV patients. The most significant improvement between eras was in outcomes of grafts from donors ≥60yr with three-yr graft survival 58.6 (51.3-65.9) vs. 75.4 (68.9-81.9), p=0.002. The use of donors ≥60 did not change between eras: 31% vs. 34%; however, utilization in HCV recipients decreased from 36% to 3% (p<0.001). In conclusion, graft survival of HCV patients has improved significantly since 2003 and was comparable to non-HCV patients up to threeyr. The change in management of donor organs into HCV and non-HCV patients likely contributed to this outcome.

Original languageEnglish (US)
Pages (from-to)E345-E355
JournalClinical Transplantation
Volume25
Issue number3
DOIs
StatePublished - May 1 2011

Keywords

  • Hepatitis C
  • Liver transplantation

ASJC Scopus subject areas

  • Transplantation

Fingerprint Dive into the research topics of 'Improving graft survival for patients undergoing liver transplantation'. Together they form a unique fingerprint.

  • Cite this

    Dickson, R. C., Pungpapong, S., Keaveny, A. P., Taner, C. B., Ghabril, M., Aranda-Michel, J., Satyanarayana, R., Bonatti, H., Kramer, D. J., & Nguyen, J. H. (2011). Improving graft survival for patients undergoing liver transplantation. Clinical Transplantation, 25(3), E345-E355. https://doi.org/10.1111/j.1399-0012.2011.01428.x