Improving measurement of the adenoma detection rate and adenoma per colonoscopy quality metric

The Indiana University experience

Charles Kahi, Krishna C. Vemulapalli, Cynthia S. Johnson, Douglas Rex

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background The adenoma detection rate (ADR) is a validated marker of colonoscopy quality. However, the optimal measurement method is unclear. Objective The aims of our study were to (1) define benchmarks for the number of adenomas per screening colonoscopy (APC) quality metric; (2) study the association between ADRs for screening, surveillance, and diagnostic indications; and (3) explore the association of the screening ADR with an overall ADR inclusive of all colonoscopy indications. Design Retrospective study. Setting University hospital and associated ambulatory surgery center endoscopy units. Patients Patients aged ≥50 years who underwent colonoscopy for screening, surveillance, or diagnostic indications by 20 endoscopists between January 1, 1999 and April 30, 2012. Intervention Colonoscopy. Main Outcome Measurements ADR, APC for screening, surveillance, and diagnostic indications. Results A total of 21,766 colonoscopies were included. The indication was screening in 7434 (34.2%), surveillance in 8338 (38.3%), and diagnostic in 5994 (27.5%). The screening ADRs and APCs were significantly correlated (R = 0.91; P <.0001). For men, an ADR of 25% corresponded to an APC of 0.46 (95% confidence interval [CI], 0.35-0.57); for women, an ADR of 15% corresponded to an APC of 0.20 (95% CI, 0.13-0.27). Overall, the ADR stratified by colonoscopy indication was highest for surveillance, followed by screening, then diagnostic. For men, a screening ADR of 25% corresponded to a surveillance ADR of 31.9% (95% CI, 24.8%-38.9%); for women, an ADR of 15% corresponded to a surveillance ADR of 24.3% (95% CI, 18.3%-30.5%). The corresponding diagnostic ADRs were 17.0% (95% CI, 12.4%-21.6%) and 15.4% (95% CI, 11.5%-19.3%), respectively. There was significant correlation between screening ADR and an overall ADR inclusive of all colonoscopy indications. Limitations External generalizability, retrospective design. Conclusion We propose minimum screening APC detection benchmarks of 0.50 for men and 0.20 for women. ADRs for screening, surveillance, and diagnostic colonoscopy are correlated and can be used to derive a simplified overall ADR inclusive of all colonoscopy indications.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalGastrointestinal Endoscopy
Volume79
Issue number3
DOIs
StatePublished - Mar 2014

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Colonoscopy
Adenoma
Confidence Intervals
Benchmarking

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Improving measurement of the adenoma detection rate and adenoma per colonoscopy quality metric : The Indiana University experience. / Kahi, Charles; Vemulapalli, Krishna C.; Johnson, Cynthia S.; Rex, Douglas.

In: Gastrointestinal Endoscopy, Vol. 79, No. 3, 03.2014, p. 448-454.

Research output: Contribution to journalArticle

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abstract = "Background The adenoma detection rate (ADR) is a validated marker of colonoscopy quality. However, the optimal measurement method is unclear. Objective The aims of our study were to (1) define benchmarks for the number of adenomas per screening colonoscopy (APC) quality metric; (2) study the association between ADRs for screening, surveillance, and diagnostic indications; and (3) explore the association of the screening ADR with an overall ADR inclusive of all colonoscopy indications. Design Retrospective study. Setting University hospital and associated ambulatory surgery center endoscopy units. Patients Patients aged ≥50 years who underwent colonoscopy for screening, surveillance, or diagnostic indications by 20 endoscopists between January 1, 1999 and April 30, 2012. Intervention Colonoscopy. Main Outcome Measurements ADR, APC for screening, surveillance, and diagnostic indications. Results A total of 21,766 colonoscopies were included. The indication was screening in 7434 (34.2{\%}), surveillance in 8338 (38.3{\%}), and diagnostic in 5994 (27.5{\%}). The screening ADRs and APCs were significantly correlated (R = 0.91; P <.0001). For men, an ADR of 25{\%} corresponded to an APC of 0.46 (95{\%} confidence interval [CI], 0.35-0.57); for women, an ADR of 15{\%} corresponded to an APC of 0.20 (95{\%} CI, 0.13-0.27). Overall, the ADR stratified by colonoscopy indication was highest for surveillance, followed by screening, then diagnostic. For men, a screening ADR of 25{\%} corresponded to a surveillance ADR of 31.9{\%} (95{\%} CI, 24.8{\%}-38.9{\%}); for women, an ADR of 15{\%} corresponded to a surveillance ADR of 24.3{\%} (95{\%} CI, 18.3{\%}-30.5{\%}). The corresponding diagnostic ADRs were 17.0{\%} (95{\%} CI, 12.4{\%}-21.6{\%}) and 15.4{\%} (95{\%} CI, 11.5{\%}-19.3{\%}), respectively. There was significant correlation between screening ADR and an overall ADR inclusive of all colonoscopy indications. Limitations External generalizability, retrospective design. Conclusion We propose minimum screening APC detection benchmarks of 0.50 for men and 0.20 for women. ADRs for screening, surveillance, and diagnostic colonoscopy are correlated and can be used to derive a simplified overall ADR inclusive of all colonoscopy indications.",
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N2 - Background The adenoma detection rate (ADR) is a validated marker of colonoscopy quality. However, the optimal measurement method is unclear. Objective The aims of our study were to (1) define benchmarks for the number of adenomas per screening colonoscopy (APC) quality metric; (2) study the association between ADRs for screening, surveillance, and diagnostic indications; and (3) explore the association of the screening ADR with an overall ADR inclusive of all colonoscopy indications. Design Retrospective study. Setting University hospital and associated ambulatory surgery center endoscopy units. Patients Patients aged ≥50 years who underwent colonoscopy for screening, surveillance, or diagnostic indications by 20 endoscopists between January 1, 1999 and April 30, 2012. Intervention Colonoscopy. Main Outcome Measurements ADR, APC for screening, surveillance, and diagnostic indications. Results A total of 21,766 colonoscopies were included. The indication was screening in 7434 (34.2%), surveillance in 8338 (38.3%), and diagnostic in 5994 (27.5%). The screening ADRs and APCs were significantly correlated (R = 0.91; P <.0001). For men, an ADR of 25% corresponded to an APC of 0.46 (95% confidence interval [CI], 0.35-0.57); for women, an ADR of 15% corresponded to an APC of 0.20 (95% CI, 0.13-0.27). Overall, the ADR stratified by colonoscopy indication was highest for surveillance, followed by screening, then diagnostic. For men, a screening ADR of 25% corresponded to a surveillance ADR of 31.9% (95% CI, 24.8%-38.9%); for women, an ADR of 15% corresponded to a surveillance ADR of 24.3% (95% CI, 18.3%-30.5%). The corresponding diagnostic ADRs were 17.0% (95% CI, 12.4%-21.6%) and 15.4% (95% CI, 11.5%-19.3%), respectively. There was significant correlation between screening ADR and an overall ADR inclusive of all colonoscopy indications. Limitations External generalizability, retrospective design. Conclusion We propose minimum screening APC detection benchmarks of 0.50 for men and 0.20 for women. ADRs for screening, surveillance, and diagnostic colonoscopy are correlated and can be used to derive a simplified overall ADR inclusive of all colonoscopy indications.

AB - Background The adenoma detection rate (ADR) is a validated marker of colonoscopy quality. However, the optimal measurement method is unclear. Objective The aims of our study were to (1) define benchmarks for the number of adenomas per screening colonoscopy (APC) quality metric; (2) study the association between ADRs for screening, surveillance, and diagnostic indications; and (3) explore the association of the screening ADR with an overall ADR inclusive of all colonoscopy indications. Design Retrospective study. Setting University hospital and associated ambulatory surgery center endoscopy units. Patients Patients aged ≥50 years who underwent colonoscopy for screening, surveillance, or diagnostic indications by 20 endoscopists between January 1, 1999 and April 30, 2012. Intervention Colonoscopy. Main Outcome Measurements ADR, APC for screening, surveillance, and diagnostic indications. Results A total of 21,766 colonoscopies were included. The indication was screening in 7434 (34.2%), surveillance in 8338 (38.3%), and diagnostic in 5994 (27.5%). The screening ADRs and APCs were significantly correlated (R = 0.91; P <.0001). For men, an ADR of 25% corresponded to an APC of 0.46 (95% confidence interval [CI], 0.35-0.57); for women, an ADR of 15% corresponded to an APC of 0.20 (95% CI, 0.13-0.27). Overall, the ADR stratified by colonoscopy indication was highest for surveillance, followed by screening, then diagnostic. For men, a screening ADR of 25% corresponded to a surveillance ADR of 31.9% (95% CI, 24.8%-38.9%); for women, an ADR of 15% corresponded to a surveillance ADR of 24.3% (95% CI, 18.3%-30.5%). The corresponding diagnostic ADRs were 17.0% (95% CI, 12.4%-21.6%) and 15.4% (95% CI, 11.5%-19.3%), respectively. There was significant correlation between screening ADR and an overall ADR inclusive of all colonoscopy indications. Limitations External generalizability, retrospective design. Conclusion We propose minimum screening APC detection benchmarks of 0.50 for men and 0.20 for women. ADRs for screening, surveillance, and diagnostic colonoscopy are correlated and can be used to derive a simplified overall ADR inclusive of all colonoscopy indications.

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