Improving sequence alignments for intrinsically disordered proteins.

Predrag Radivojac, Zoran Obradovic, Celeste J. Brown, A. Dunker

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

Here we analyze sequence alignments for intrinsically disordered proteins. For 55 disordered protein families we measure the performance of different scoring matrices and propose one adjusted to disordered regions. An iterative algorithm of realigning sequences and recalculating matrices is designed and tested. For each matrix we also test a wide range of gap penalties. Results show an improvement in the ability to detect and discriminate related disordered proteins whose average sequence identity with the other family members is below 50%.

Original languageEnglish (US)
Title of host publicationPacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Pages589-600
Number of pages12
StatePublished - 2002
Externally publishedYes

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Intrinsically Disordered Proteins
Sequence Alignment
Aptitude
Proteins

Cite this

Radivojac, P., Obradovic, Z., Brown, C. J., & Dunker, A. (2002). Improving sequence alignments for intrinsically disordered proteins. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing (pp. 589-600)

Improving sequence alignments for intrinsically disordered proteins. / Radivojac, Predrag; Obradovic, Zoran; Brown, Celeste J.; Dunker, A.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2002. p. 589-600.

Research output: Chapter in Book/Report/Conference proceedingChapter

Radivojac, P, Obradovic, Z, Brown, CJ & Dunker, A 2002, Improving sequence alignments for intrinsically disordered proteins. in Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. pp. 589-600.
Radivojac P, Obradovic Z, Brown CJ, Dunker A. Improving sequence alignments for intrinsically disordered proteins. In Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2002. p. 589-600
Radivojac, Predrag ; Obradovic, Zoran ; Brown, Celeste J. ; Dunker, A. / Improving sequence alignments for intrinsically disordered proteins. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing. 2002. pp. 589-600
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