Improving transparency and reproducibility through registration: The status of intervention trials published in clinical psychology journals

Lukasz Cybulski, Evan Mayo-Wilson, Sean Grant

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Objective: Prospective registration increases the validity of randomized controlled trials (RCTs). In the United States, registration is a legal requirement for drugs and devices regulated by the Food and Drug Administration (FDA), and many biomedical journals refuse to publish trials that are not registered. Trials in clinical psychology have not been subject to these requirements; it is unknown to what extent they are registered. Method: We searched the 25 highest-impact clinical psychology journals that published at least 1 RCT of a health-related psychological intervention in 2013. For included trials, we evaluated their registration status (prospective, retrospective, not registered) and the completeness of their outcome definitions. Results: We identified 163 articles that reported 165 RCTs; 73 (44%) RCTs were registered, of which only 25 (15%) were registered prospectively. Of registered RCTs, only 42 (58%) indicated their registration status in the publication. Only 2 (1% of all trials) were registered prospectively and defined their primary outcomes completely. For the primary outcome(s), 72 (99%) of all registrations defined the domain, 67 (92%) the time frame, and 48 (66%) the specific measurements. Only 19 (26%) and 5 (7%) defined the specific metric and method of aggregation, respectively, for all primary outcomes. Conclusions: Very few reports of RCTs published in clinical psychology journals were registered prospectively and completely. Clinical psychology journals could improve transparency and reproducibility, as well as reduce bias, by requiring complete prospective trial registration for publication and by including trial registration numbers in all reports of RCTs.

Original languageEnglish (US)
Pages (from-to)753-767
Number of pages15
JournalJournal of Consulting and Clinical Psychology
Volume84
Issue number9
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Keywords

  • intervention research
  • randomized controlled trials
  • reporting bias
  • reporting guidelines
  • trial registration

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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