In Situ Study to Confirm the Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate

C. R. Parkinson, M. Siddiqi, S. Mason, Frank Lippert, Anderson Hara, Domenick Zero

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2 Citations (Scopus)

Abstract

OBJECTIVES: A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model.

METHODS: Seventy-seven subjects wearing bilateral mandibular partial dentures holding partially demineralized bovine enamel specimens 24 hours/day brushed their teeth with their assigned randomized dentifrice containing either 1500 or 0 ppm F with 5% CSPS or 1500, 500, or 0 ppm F with 0% CSPS twice daily for 21 days. The success criterion was to observe a difference in % SMHR between dentifrices containing 1500 ppm F of six units or less in the upper bound of the two-sided 95% confidence interval (CI).

RESULTS: Following 21 days of treatment, the upper bound CI of the %SMHR difference between the dentifrices containing 1500 ppm F was 1.66, thus within the non-inferiority limit. No statistically significant differences for %SMHR (p = 0.2601) and EFU (p = 0.2984) were noted between these two dentifrices.

CONCLUSIONS: The present in situ caries study provides evidence demonstrating that the addition of the calcium-containing compound CSPS to a 1500 ppm F dentifrice does not interfere with the ability of fluoride to remineralize surface-softened enamel; i.e., CSPS neither impairs nor improves the potential cariostatic value of SMFP dentifrice.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalThe Journal of clinical dentistry
Volume28
Issue number2
StatePublished - Jun 1 2017

Fingerprint

fluorophosphate
Dentifrices
Sodium
Dental Enamel
Calcium
Fluorides
Calcium Compounds
Dentin Sensitivity
Partial Denture
Confidence Intervals
Tooth

Keywords

  • calcium sodium phosphosilicate (CSPS)
  • caries
  • dentifrice
  • fluoride
  • in situ model
  • NovaMin®

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

@article{f57c564d4066483e95e289eac3e1dbcb,
title = "In Situ Study to Confirm the Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate",
abstract = "OBJECTIVES: A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery ({\%}SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model.METHODS: Seventy-seven subjects wearing bilateral mandibular partial dentures holding partially demineralized bovine enamel specimens 24 hours/day brushed their teeth with their assigned randomized dentifrice containing either 1500 or 0 ppm F with 5{\%} CSPS or 1500, 500, or 0 ppm F with 0{\%} CSPS twice daily for 21 days. The success criterion was to observe a difference in {\%} SMHR between dentifrices containing 1500 ppm F of six units or less in the upper bound of the two-sided 95{\%} confidence interval (CI).RESULTS: Following 21 days of treatment, the upper bound CI of the {\%}SMHR difference between the dentifrices containing 1500 ppm F was 1.66, thus within the non-inferiority limit. No statistically significant differences for {\%}SMHR (p = 0.2601) and EFU (p = 0.2984) were noted between these two dentifrices.CONCLUSIONS: The present in situ caries study provides evidence demonstrating that the addition of the calcium-containing compound CSPS to a 1500 ppm F dentifrice does not interfere with the ability of fluoride to remineralize surface-softened enamel; i.e., CSPS neither impairs nor improves the potential cariostatic value of SMFP dentifrice.",
keywords = "calcium sodium phosphosilicate (CSPS), caries, dentifrice, fluoride, in situ model, NovaMin{\circledR}",
author = "Parkinson, {C. R.} and M. Siddiqi and S. Mason and Frank Lippert and Anderson Hara and Domenick Zero",
year = "2017",
month = "6",
day = "1",
language = "English (US)",
volume = "28",
pages = "27--31",
journal = "Journal of Clinical Dentistry",
issn = "0895-8831",
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number = "2",

}

TY - JOUR

T1 - In Situ Study to Confirm the Anticaries Potential of a Sodium Monofluorophosphate Dentifrice Containing Calcium Sodium Phosphosilicate

AU - Parkinson, C. R.

AU - Siddiqi, M.

AU - Mason, S.

AU - Lippert, Frank

AU - Hara, Anderson

AU - Zero, Domenick

PY - 2017/6/1

Y1 - 2017/6/1

N2 - OBJECTIVES: A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model.METHODS: Seventy-seven subjects wearing bilateral mandibular partial dentures holding partially demineralized bovine enamel specimens 24 hours/day brushed their teeth with their assigned randomized dentifrice containing either 1500 or 0 ppm F with 5% CSPS or 1500, 500, or 0 ppm F with 0% CSPS twice daily for 21 days. The success criterion was to observe a difference in % SMHR between dentifrices containing 1500 ppm F of six units or less in the upper bound of the two-sided 95% confidence interval (CI).RESULTS: Following 21 days of treatment, the upper bound CI of the %SMHR difference between the dentifrices containing 1500 ppm F was 1.66, thus within the non-inferiority limit. No statistically significant differences for %SMHR (p = 0.2601) and EFU (p = 0.2984) were noted between these two dentifrices.CONCLUSIONS: The present in situ caries study provides evidence demonstrating that the addition of the calcium-containing compound CSPS to a 1500 ppm F dentifrice does not interfere with the ability of fluoride to remineralize surface-softened enamel; i.e., CSPS neither impairs nor improves the potential cariostatic value of SMFP dentifrice.

AB - OBJECTIVES: A randomized, investigator-blind, five-treatment, crossover, non-inferiority study was conducted to investigate the effect of the addition of calcium sodium phosphosilicate (CSPS), an agent known to relieve dentin hypersensitivity, to a sodium monofluorophosphate (SMFP)-containing dentifrice on the enamel remineralization potential of fluoride (F), as assessed by percentage surface microhardness recovery (%SMHR) and enamel fluoride uptake (EFU) using a standard in situ caries model.METHODS: Seventy-seven subjects wearing bilateral mandibular partial dentures holding partially demineralized bovine enamel specimens 24 hours/day brushed their teeth with their assigned randomized dentifrice containing either 1500 or 0 ppm F with 5% CSPS or 1500, 500, or 0 ppm F with 0% CSPS twice daily for 21 days. The success criterion was to observe a difference in % SMHR between dentifrices containing 1500 ppm F of six units or less in the upper bound of the two-sided 95% confidence interval (CI).RESULTS: Following 21 days of treatment, the upper bound CI of the %SMHR difference between the dentifrices containing 1500 ppm F was 1.66, thus within the non-inferiority limit. No statistically significant differences for %SMHR (p = 0.2601) and EFU (p = 0.2984) were noted between these two dentifrices.CONCLUSIONS: The present in situ caries study provides evidence demonstrating that the addition of the calcium-containing compound CSPS to a 1500 ppm F dentifrice does not interfere with the ability of fluoride to remineralize surface-softened enamel; i.e., CSPS neither impairs nor improves the potential cariostatic value of SMFP dentifrice.

KW - calcium sodium phosphosilicate (CSPS)

KW - caries

KW - dentifrice

KW - fluoride

KW - in situ model

KW - NovaMin®

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M3 - Article

C2 - 28657702

AN - SCOPUS:85037868314

VL - 28

SP - 27

EP - 31

JO - Journal of Clinical Dentistry

JF - Journal of Clinical Dentistry

SN - 0895-8831

IS - 2

ER -