In utero brain destruction resulting in collapse of the fetal skull, microcephaly, scalp rugae, and neurologic impairment: The fetal brain disruption sequence

L. J. Russell, D. D. Weaver, M. J. Bull, M. Weinbaum

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Three infants are reported with a recognizable pattern of defects consisting of severe microcephaly, overlapping sutures, prominence of the occipital bone, and scalp rugae. This condition, which we think represents microhydranencephaly appears to be produced by partial brain destruction during the second or third trimester, diminution in intracranial hydrostatic pressure, and subsequent collapse of the fetal skull. Several different causes for this condition have been suggested including partial disruption of the blood supply to the brain and prenatal viral infection.

Original languageEnglish (US)
Pages (from-to)509-521
Number of pages13
JournalAmerican Journal of Medical Genetics
Volume17
Issue number2
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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