In vitro ablation of cardiac valves using high-intensity focused ultrasound

Ryo Otsuka, Kana Fujikura, Kumiko Hirata, Todd Pulerwitz, Yukiko Oe, Takeki Suzuki, Robert Sciacca, Charles Marboe, Jie Wang, Daniel Burkhoff, Robert Muratore, Frederic L. Lizzi, Shunichi Homma

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The purpose of this study was to evaluate the possibility of using high-intensity focused ultrasound (US), or HIFU, to create lesions in cardiac valves in vitro. Calf mitral valves and aortic valves were examined. Focused US energy was applied with an operating frequency of 4.67 MHz at a nominal acoustic power of 58 W for 0.2, 0.3 and 0.4 s at 4-s intervals. Mitral valve perforation was achieved with 20.8 ± 3.7 exposures of 0.2 s, 15.4 ± 2.1 exposures of 0.3 s or 11.2 ± 2.3 exposures of 0.4 s. Aortic valve perforation was achieved with 13.3 ± 2.4 exposures of 0.2 s, 10.3 ± 2.2 exposures of 0.3 s or 8.4 ± 1.8 exposures of 0.4 s. The mean diameter of the perforated area was 1.09 ± 0.11 mm. The lesions were slightly discolored and coagulation of tissue around the perforation was observed. HIFU was successful in perforating cardiac valves. With further refinement, HIFU may prove useful for valvulotomy or valvuloplasty.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalUltrasound in Medicine and Biology
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Keywords

  • Ablation
  • Cardiac valve
  • High-intensity focused ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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  • Cite this

    Otsuka, R., Fujikura, K., Hirata, K., Pulerwitz, T., Oe, Y., Suzuki, T., Sciacca, R., Marboe, C., Wang, J., Burkhoff, D., Muratore, R., Lizzi, F. L., & Homma, S. (2005). In vitro ablation of cardiac valves using high-intensity focused ultrasound. Ultrasound in Medicine and Biology, 31(1), 109-114. https://doi.org/10.1016/j.ultrasmedbio.2004.09.009