In vitro activities of acridone alkaloids against Pneumocystis carinii

Sherry Queener, H. Fujioka, Y. Nishiyama, H. Furukawa, M. S. Bartlett, J. W. Smith

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 μM, respectively. This potency of effect is similar to that of chloroquine (3 μM) but somewhat less than that of primaquine (0.4 μM), which was previously evaluated in the same system.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number2
StatePublished - 1991

Fingerprint

Pneumocystis carinii
Alkaloids
Primaquine
Rutaceae
Chloroquine
Antimalarials
Malaria
Rodentia
Growth
In Vitro Techniques
acridone

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Queener, S., Fujioka, H., Nishiyama, Y., Furukawa, H., Bartlett, M. S., & Smith, J. W. (1991). In vitro activities of acridone alkaloids against Pneumocystis carinii. Antimicrobial Agents and Chemotherapy, 35(2), 377-379.

In vitro activities of acridone alkaloids against Pneumocystis carinii. / Queener, Sherry; Fujioka, H.; Nishiyama, Y.; Furukawa, H.; Bartlett, M. S.; Smith, J. W.

In: Antimicrobial Agents and Chemotherapy, Vol. 35, No. 2, 1991, p. 377-379.

Research output: Contribution to journalArticle

Queener, S, Fujioka, H, Nishiyama, Y, Furukawa, H, Bartlett, MS & Smith, JW 1991, 'In vitro activities of acridone alkaloids against Pneumocystis carinii', Antimicrobial Agents and Chemotherapy, vol. 35, no. 2, pp. 377-379.
Queener S, Fujioka H, Nishiyama Y, Furukawa H, Bartlett MS, Smith JW. In vitro activities of acridone alkaloids against Pneumocystis carinii. Antimicrobial Agents and Chemotherapy. 1991;35(2):377-379.
Queener, Sherry ; Fujioka, H. ; Nishiyama, Y. ; Furukawa, H. ; Bartlett, M. S. ; Smith, J. W. / In vitro activities of acridone alkaloids against Pneumocystis carinii. In: Antimicrobial Agents and Chemotherapy. 1991 ; Vol. 35, No. 2. pp. 377-379.
@article{92826bf1bcef47a286431e5fd17d4a90,
title = "In vitro activities of acridone alkaloids against Pneumocystis carinii",
abstract = "Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 μM, respectively. This potency of effect is similar to that of chloroquine (3 μM) but somewhat less than that of primaquine (0.4 μM), which was previously evaluated in the same system.",
author = "Sherry Queener and H. Fujioka and Y. Nishiyama and H. Furukawa and Bartlett, {M. S.} and Smith, {J. W.}",
year = "1991",
language = "English",
volume = "35",
pages = "377--379",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "2",

}

TY - JOUR

T1 - In vitro activities of acridone alkaloids against Pneumocystis carinii

AU - Queener, Sherry

AU - Fujioka, H.

AU - Nishiyama, Y.

AU - Furukawa, H.

AU - Bartlett, M. S.

AU - Smith, J. W.

PY - 1991

Y1 - 1991

N2 - Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 μM, respectively. This potency of effect is similar to that of chloroquine (3 μM) but somewhat less than that of primaquine (0.4 μM), which was previously evaluated in the same system.

AB - Acridone alkaloids isolated from plants of the family Rutaceae have antiplasmodial activity in rodent models of malaria. Because a variety of antimalarial agents have also been shown to have activity against Pneumocystis carinii, we tested six of these alkaloids in an established culture model for P. carinii. Atalaphillinine and glycobismine A inhibited growth of cultured P. carinii at concentrations of 2.7 and 1.7 μM, respectively. This potency of effect is similar to that of chloroquine (3 μM) but somewhat less than that of primaquine (0.4 μM), which was previously evaluated in the same system.

UR - http://www.scopus.com/inward/record.url?scp=0026063983&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026063983&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 377

EP - 379

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 2

ER -