In vitro and in vivo activities of E-101 solution against Acinetobacter baumannii isolates from U.S. military personnel

G. A. Denys, J. C. Davis, P. D. O'Hanley, J. T. Stephens

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We evaluated the in vitro and in vivo activity of a novel topical myeloperoxidase-mediated antimicrobial, E-101 solution, against 5 multidrug-resistant Acinetobacter baumannii isolates recovered from wounded American soldiers. Time-kill studies demonstrated rapid bactericidal activity against all A. baumannii strains tested in the presence of 3% blood. The in vitro bactericidal activity of E-101 solution against A. baumannii strains was confirmed in a full-thickness excision rat model. Additional in vivo studies appear warranted.

Original languageEnglish (US)
Pages (from-to)3603-3608
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number7
DOIs
StatePublished - Jul 1 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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