In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome

F. González, N. S. Rote, J. Minium, J. P. Kirwan

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic low-level inflammation. The purpose of this study was to determine the effects of hyperglycemia in vitro on tumor necrosis factor (TNF)-α release from mononuclear cells (MNC) in PCOS. Twelve reproductive-age women with PCOS (six lean, six obese) and 12 age-matched controls (six lean, six obese) were studied. Insulin sensitivity (ISHOMA) was estimated from fasting levels of glucose and insulin and percent truncal fat was determined by dual energy absorptiometry (DEXA). TNFα release was measured from MNC cultured under euglycemic and hyperglycemic conditions. ISHOMA was higher in obese women with PCOS than in lean women with PCOS (student's t-test; 73.7 ± 14.8 vs 43.1 ± 8.6, PHOMA was positively correlated with percent truncal fat (r=0.57, PHOMA (r=0.40, P

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalJournal of Endocrinology
Volume188
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

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Polycystic Ovary Syndrome
Hyperglycemia
Tumor Necrosis Factor-alpha
Fats
Insulin
Insulin Resistance
Cultured Cells
Fasting
In Vitro Techniques
Students
Inflammation
Glucose

ASJC Scopus subject areas

  • Endocrinology

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In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome. / González, F.; Rote, N. S.; Minium, J.; Kirwan, J. P.

In: Journal of Endocrinology, Vol. 188, No. 3, 03.2006, p. 521-529.

Research output: Contribution to journalArticle

González, F. ; Rote, N. S. ; Minium, J. ; Kirwan, J. P. / In vitro evidence that hyperglycemia stimulates tumor necrosis factor-α release in obese women with polycystic ovary syndrome. In: Journal of Endocrinology. 2006 ; Vol. 188, No. 3. pp. 521-529.
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