In vitro granulocytic stem cell clonogenic capacity of marrow and spleen cells from mice infected with rauscher leukemia virus

Leonard A. Koltun, Hal Broxmeyer, Joseph Lobue, Torgny N. Fredrickson, Albert S. Gordon, Vincent Gallicchio

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Bone marrow and spleen cells from early, midstage, and terminal Rauscher leukemia virus (RLV‐A)‐infected erythroleukemic mice were assessed for granulocyte stem cell (CFU‐c) clonogenic capacity in the semisolid agar culture assay. It was found that marrow CFU‐c concentrations exceeded normal in early stages of this erythroid disease but returned to near normal values during mid‐ and terminal phases. Splenic CFU‐c concentrations, on the other hand, were generally higher than control values for all stages of the disease. These results are discussed with reference to the pathogenesis of RLV‐A disease.

Original languageEnglish (US)
Pages (from-to)253-256
Number of pages4
JournalJournal of Surgical Oncology
Volume8
Issue number3
DOIs
StatePublished - 1976
Externally publishedYes

Keywords

  • Rauscher leukemia
  • granulocytic colonies
  • marrow and spleen stem cells

ASJC Scopus subject areas

  • Surgery
  • Oncology

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