In Vitro models for neuroelectrodes: A paradigm for studying tissue-materials interactions in the brain

Vadim Polikov, Michelle Block, Cen Zhang, W. Monty Reichert, J. S. Hong

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Currently, the detailed mechanisms responsible for the electrode-tissue interactions leading to the formation of the glial scar around chronically implanted neuron-recording electrodes are poorly understood. As a consequence, the long-term use of electrodes for human prosthetics largely remains an untapped therapeutic resource. In this chapter, we will define currently available in vitro models that have the potential to uncover how the glial scar impedes brain electrode function and that provide a test bed to screen potential therapeutic compounds. Further, we will discuss the strengths and weaknesses of each of the in vitro models and explain how this line of inquiry could advance the field.

Original languageEnglish (US)
Title of host publicationIndwelling Neural Implants
Subtitle of host publicationStrategies for Contending with the in Vivo Environment
PublisherCRC Press
Pages89-115
Number of pages27
ISBN (Electronic)9781420009309
ISBN (Print)9780849393624
StatePublished - Jan 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Polikov, V., Block, M., Zhang, C., Monty Reichert, W., & Hong, J. S. (2007). In Vitro models for neuroelectrodes: A paradigm for studying tissue-materials interactions in the brain. In Indwelling Neural Implants: Strategies for Contending with the in Vivo Environment (pp. 89-115). CRC Press.