Currently, the detailed mechanisms responsible for the electrode-tissue interactions leading to the formation of the glial scar around chronically implanted neuron-recording electrodes are poorly understood. As a consequence, the long-term use of electrodes for human prosthetics largely remains an untapped therapeutic resource. In this chapter, we will define currently available in vitro models that have the potential to uncover how the glial scar impedes brain electrode function and that provide a test bed to screen potential therapeutic compounds. Further, we will discuss the strengths and weaknesses of each of the in vitro models and explain how this line of inquiry could advance the field.
|Original language||English (US)|
|Title of host publication||Indwelling Neural Implants|
|Subtitle of host publication||Strategies for Contending with the in Vivo Environment|
|Number of pages||27|
|State||Published - Jan 1 2007|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)