In vivo biologic activities of recombinant human granulocyte-macrophage colony-stimulating factor

S. Vadhan-Raj, W. N. Hittelman, Hal Broxmeyer, M. Keating, D. Urdal, J. U. Gutterman

Research output: Contribution to journalArticle

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Abstract

We evaluated the biologic effects of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) in 25 patients with malignancy and/or bone marrow failure of diverse etiologies. The continuous infusino of GM-CSF (15 to 500 μg/m2/day) elicited marked leukocytosis (2- to 70-fold increase), consisting primarily of neutrophils, eosinophils, and monocytes. Six patients with cytopenias experienced a multilineage response characterized by significant increases in platelet counts and improvement in erythropoiesis. Response in blood counts was accompanied by significant increases in bone marrow cellularity, myeloid:erythroid cell ratios, and frequency of cycling progenitors, indicating an effect at the stem cell level. By premature chromosome condensation analysis, neutrophils from patients with myeloid diseases were found to be derived from normal as well as abnormal clones. Side effects were generally mild and commonly included constitutional symptoms and bone pain. These results indicate that GM-CSF is a significant stimulus for hematopoiesis in vivo and might play an important role in several clinical arenas.

Original languageEnglish (US)
Pages (from-to)231-240
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume554
StatePublished - 1989

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Granulocyte-Macrophage Colony-Stimulating Factor
Human Activities
Bone
Neutrophils
Bone Marrow
Erythroid Cells
Erythropoiesis
Leukocytosis
Hematopoiesis
Myeloid Cells
Chromosomes
Platelets
Stem cells
Platelet Count
Eosinophils
Monocytes
Condensation
Blood
Stem Cells
Clone Cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Vadhan-Raj, S., Hittelman, W. N., Broxmeyer, H., Keating, M., Urdal, D., & Gutterman, J. U. (1989). In vivo biologic activities of recombinant human granulocyte-macrophage colony-stimulating factor. Annals of the New York Academy of Sciences, 554, 231-240.

In vivo biologic activities of recombinant human granulocyte-macrophage colony-stimulating factor. / Vadhan-Raj, S.; Hittelman, W. N.; Broxmeyer, Hal; Keating, M.; Urdal, D.; Gutterman, J. U.

In: Annals of the New York Academy of Sciences, Vol. 554, 1989, p. 231-240.

Research output: Contribution to journalArticle

Vadhan-Raj, S. ; Hittelman, W. N. ; Broxmeyer, Hal ; Keating, M. ; Urdal, D. ; Gutterman, J. U. / In vivo biologic activities of recombinant human granulocyte-macrophage colony-stimulating factor. In: Annals of the New York Academy of Sciences. 1989 ; Vol. 554. pp. 231-240.
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