In vivo evaluation of 13-93 bioactive glass scaffolds made by selective laser sintering (SLS)

M. Velez, S. Jung, K. C.R. Kolan, M. C. Leu, D. E. Day, T. M.G. Chu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations

Abstract

Bioactive glass is a synthetic material that reacts in vivo and forms an inorganic hydroxyapatite-like (HA) phase that mimics the HA found in human bone and can stimulate osteoconduction. Selective Laser Sintering (SLS) was used to fabricate "green" bone scaffolds from 13-93 bioactive glass particles (<75 urn) mixed with stearic acid. After heat treatment, the scaffolds had a hollow cylindrical shape that was intended to mimic the structure and mechanical properties of human trabecular bone. In vitro, the compressive strength of the SLS scaffolds was measured as a function of time for up to two months when immersed in Dulbecco's Modified Eagles Medium (DMEM) at 38°C. In vivo, the cylindrical scaffolds with and without bone morphogenic protein-2 (BMP-2), were implanted in rat femurs for up to three months. The data from the in vivo study is compared to similar biodegradable polymer scaffolds treated with BMP-2 in critical sized defects in rats.

Original languageEnglish (US)
Title of host publicationBiomaterials Science
Subtitle of host publicationProcessing, Properties and Applications II
PublisherAmerican Ceramic Society
Pages91-99
Number of pages9
ISBN (Print)9781118273326
DOIs
StatePublished - Jan 1 2012
EventNext Generation Biomaterials and Surface Properties of Biomaterials Symposia - Materials Science and Technology 2011 Conference and Exhibition, MS and T 2011 - Columbus, OH, United States
Duration: Oct 16 2011Oct 20 2011

Publication series

NameCeramic Transactions
Volume237
ISSN (Print)1042-1122

Other

OtherNext Generation Biomaterials and Surface Properties of Biomaterials Symposia - Materials Science and Technology 2011 Conference and Exhibition, MS and T 2011
CountryUnited States
CityColumbus, OH
Period10/16/1110/20/11

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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    Velez, M., Jung, S., Kolan, K. C. R., Leu, M. C., Day, D. E., & Chu, T. M. G. (2012). In vivo evaluation of 13-93 bioactive glass scaffolds made by selective laser sintering (SLS). In Biomaterials Science: Processing, Properties and Applications II (pp. 91-99). (Ceramic Transactions; Vol. 237). American Ceramic Society. https://doi.org/10.1002/9781118511466.ch10