In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus

T. M. Gao, Z. C. Xu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Pyramidal neurons in the CA1 field of the hippocampus die a few days after transient cerebral ischemia. Excessive excitatory synaptic activation following reperfusion is thought to be responsible for such delayed cell death. However, it remains controversial whether excitatory synaptic transmission in the CA1 field is increased following reperfusion. Here we report a novel postsynaptic potential evoked from CA1 pyramidal neurons preceding cell death after transient forebrain ischemia with intracellular recording and staining techniques in vivo. This result indicates the dramatic alteration of synaptic transmission in CA1 neurons after transient ischemia. The ischemia-induced postsynaptic potential may be associated with the postischemic neuronal injury.

Original languageEnglish (US)
Pages (from-to)665-669
Number of pages5
JournalNeuroscience
Volume75
Issue number3
DOIs
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Synaptic Potentials
Pyramidal Cells
Hippocampus
Ischemia
Synaptic Transmission
Reperfusion
Cell Death
Hippocampal CA1 Region
Transient Ischemic Attack
Prosencephalon
Staining and Labeling
Neurons
Wounds and Injuries

Keywords

  • excitotoxic
  • intracellular recording
  • neurophysiology
  • synaptic transmission
  • transient cerebral ischemia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

In vivo intracellular demonstration of an ischemia-induced postsynaptic potential from CA1 pyramidal neurons in rat hippocampus. / Gao, T. M.; Xu, Z. C.

In: Neuroscience, Vol. 75, No. 3, 12.1996, p. 665-669.

Research output: Contribution to journalArticle

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