In Vivo Microscopy in Neurosurgical Oncology

Hany Osman, Joseph Georges, Deena Elsahy, Eyas M. Hattab, Steven Yocom, Aaron A. Cohen-Gadol

Research output: Contribution to journalReview article

8 Scopus citations


Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Although useful, these techniques are time consuming and therefore cannot provide real-time intraoperative feedback. In vivo molecular imaging techniques are emerging as novel methods for generating real-time diagnostic histopathologic images of tumors and their surrounding tissues. These imaging techniques rely on contrast generated by exogenous fluorescent dyes, autofluorescence of endogenous molecules, fluorescence decay of excited molecules, or light scattering. Large molecular imaging instruments are being miniaturized for clinical in vivo use. This review discusses pertinent imaging systems that have been developed for neurosurgical use and imaging techniques currently under development for neurosurgical molecular imaging.

Original languageEnglish (US)
Pages (from-to)110-127
Number of pages18
JournalWorld Neurosurgery
StatePublished - Jul 2018


  • Glioma
  • In vivo
  • Microscopy
  • Neurosurgery
  • Oncology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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  • Cite this

    Osman, H., Georges, J., Elsahy, D., Hattab, E. M., Yocom, S., & Cohen-Gadol, A. A. (2018). In Vivo Microscopy in Neurosurgical Oncology. World Neurosurgery, 115, 110-127.