In Vivo Microscopy in Neurosurgical Oncology

Hany Osman, Joseph Georges, Deena Elsahy, Eyas M. Hattab, Steven Yocom, Aaron Cohen-Gadol

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Although useful, these techniques are time consuming and therefore cannot provide real-time intraoperative feedback. In vivo molecular imaging techniques are emerging as novel methods for generating real-time diagnostic histopathologic images of tumors and their surrounding tissues. These imaging techniques rely on contrast generated by exogenous fluorescent dyes, autofluorescence of endogenous molecules, fluorescence decay of excited molecules, or light scattering. Large molecular imaging instruments are being miniaturized for clinical in vivo use. This review discusses pertinent imaging systems that have been developed for neurosurgical use and imaging techniques currently under development for neurosurgical molecular imaging.

Original languageEnglish (US)
Pages (from-to)110-127
Number of pages18
JournalWorld Neurosurgery
Volume115
DOIs
StatePublished - Jul 1 2018

Fingerprint

Molecular Imaging
Light
Frozen Sections
Fluorescent Dyes
Microscopy
Fluorescence
Intravital Microscopy
Neoplasms

Keywords

  • Glioma
  • In vivo
  • Microscopy
  • Neurosurgery
  • Oncology

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Osman, H., Georges, J., Elsahy, D., Hattab, E. M., Yocom, S., & Cohen-Gadol, A. (2018). In Vivo Microscopy in Neurosurgical Oncology. World Neurosurgery, 115, 110-127. https://doi.org/10.1016/j.wneu.2018.03.218

In Vivo Microscopy in Neurosurgical Oncology. / Osman, Hany; Georges, Joseph; Elsahy, Deena; Hattab, Eyas M.; Yocom, Steven; Cohen-Gadol, Aaron.

In: World Neurosurgery, Vol. 115, 01.07.2018, p. 110-127.

Research output: Contribution to journalReview article

Osman, H, Georges, J, Elsahy, D, Hattab, EM, Yocom, S & Cohen-Gadol, A 2018, 'In Vivo Microscopy in Neurosurgical Oncology', World Neurosurgery, vol. 115, pp. 110-127. https://doi.org/10.1016/j.wneu.2018.03.218
Osman, Hany ; Georges, Joseph ; Elsahy, Deena ; Hattab, Eyas M. ; Yocom, Steven ; Cohen-Gadol, Aaron. / In Vivo Microscopy in Neurosurgical Oncology. In: World Neurosurgery. 2018 ; Vol. 115. pp. 110-127.
@article{96d349c6d0ab4f6cad2e2aa46eaf4530,
title = "In Vivo Microscopy in Neurosurgical Oncology",
abstract = "Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Although useful, these techniques are time consuming and therefore cannot provide real-time intraoperative feedback. In vivo molecular imaging techniques are emerging as novel methods for generating real-time diagnostic histopathologic images of tumors and their surrounding tissues. These imaging techniques rely on contrast generated by exogenous fluorescent dyes, autofluorescence of endogenous molecules, fluorescence decay of excited molecules, or light scattering. Large molecular imaging instruments are being miniaturized for clinical in vivo use. This review discusses pertinent imaging systems that have been developed for neurosurgical use and imaging techniques currently under development for neurosurgical molecular imaging.",
keywords = "Glioma, In vivo, Microscopy, Neurosurgery, Oncology",
author = "Hany Osman and Joseph Georges and Deena Elsahy and Hattab, {Eyas M.} and Steven Yocom and Aaron Cohen-Gadol",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.wneu.2018.03.218",
language = "English (US)",
volume = "115",
pages = "110--127",
journal = "World Neurosurgery",
issn = "1878-8750",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - In Vivo Microscopy in Neurosurgical Oncology

AU - Osman, Hany

AU - Georges, Joseph

AU - Elsahy, Deena

AU - Hattab, Eyas M.

AU - Yocom, Steven

AU - Cohen-Gadol, Aaron

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Although useful, these techniques are time consuming and therefore cannot provide real-time intraoperative feedback. In vivo molecular imaging techniques are emerging as novel methods for generating real-time diagnostic histopathologic images of tumors and their surrounding tissues. These imaging techniques rely on contrast generated by exogenous fluorescent dyes, autofluorescence of endogenous molecules, fluorescence decay of excited molecules, or light scattering. Large molecular imaging instruments are being miniaturized for clinical in vivo use. This review discusses pertinent imaging systems that have been developed for neurosurgical use and imaging techniques currently under development for neurosurgical molecular imaging.

AB - Intraoperative neurosurgical histopathologic diagnoses rely on evaluation of rapid tissue preparations such as frozen sections and smears with conventional light microscopy. Although useful, these techniques are time consuming and therefore cannot provide real-time intraoperative feedback. In vivo molecular imaging techniques are emerging as novel methods for generating real-time diagnostic histopathologic images of tumors and their surrounding tissues. These imaging techniques rely on contrast generated by exogenous fluorescent dyes, autofluorescence of endogenous molecules, fluorescence decay of excited molecules, or light scattering. Large molecular imaging instruments are being miniaturized for clinical in vivo use. This review discusses pertinent imaging systems that have been developed for neurosurgical use and imaging techniques currently under development for neurosurgical molecular imaging.

KW - Glioma

KW - In vivo

KW - Microscopy

KW - Neurosurgery

KW - Oncology

UR - http://www.scopus.com/inward/record.url?scp=85047323784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047323784&partnerID=8YFLogxK

U2 - 10.1016/j.wneu.2018.03.218

DO - 10.1016/j.wneu.2018.03.218

M3 - Review article

VL - 115

SP - 110

EP - 127

JO - World Neurosurgery

JF - World Neurosurgery

SN - 1878-8750

ER -