In vivo modulation of signaling factors involved in cell survival

Anirban Kumar Mitra, Malini Krishna

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In vivo expression of cell survival factors protein kinase C (PKC), nuclear factor κB (NFκB), and extracellular signal-regulated kinase (Erk), which may contribute to the development of radioresistance following radiotherapy, was looked for. Their modulation with natural compounds (curcumin, rutin or nicotinamide) was attempted in mice bearing a serially transplanted fibrosarcoma. Expression of protein kinase C was isoform specific. No translocation of any of the isozymes was noticed following γ-irradiation as has been reported elsewhere. None of the isoforms could be significantly inhibited by the modulators. However, significant inhibition of radiation-induced ERK and NFκB was observed with both curcumin and nicotinamide. Therefore we conclude that use of inhibitors of MAP kinases or NFκB may be a more promising strategy to enhance tumour cell killing or to prevent the development of radioresistance during radiotherapy.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalJournal of Radiation Research
Volume45
Issue number4
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • ERK
  • NF-κB
  • PKC
  • Radiation and fibrosarcoma

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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