In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats

H. Bohlen, D. Lobach

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

This study was designed to determine if vessel wall hypertrophy and increased expression of sympathetic activity occur in the microcirculation during the development of hypertension. The cremaster muscle microvasculature of normal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats was observed at age 5-7 wk and 16-18 wk. For age-matched WKY and SHR rats, the diameters, wall thicknesses and vessel wall cross-sectional areas for the majority of comparable types of arterioles were not significantly (p > 0.05) different. After denervation of the cremasteric muscle, the large and intermediate diameter arterioles of young WKY rats dilated significantly (p < 0.005) more than did comparable vessels of SHR rats. In contrast, the dilation of comparable types of arterioles in mature WKY and SHR rats following denervation was not significantly (p > 0.05) different. The results do not support either abnormal vessel wall hypertrophy, vasoconstriction or increased expression of sympathetic activity in SHR rats compared to WKY rats up to age 16-18 wk.

Original languageEnglish
Pages (from-to)322-330
Number of pages9
JournalBlood Vessels
Volume15
Issue number5
StatePublished - 1978

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Inbred SHR Rats
Inbred WKY Rats
Arterioles
Hypertrophy
Muscle Denervation
Abdominal Muscles
Microcirculation
Microvessels
Vasoconstriction
Hypertension

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

In vivo study of microvascular wall characteristics and resting control in young and mature spontaneously hypertensive rats. / Bohlen, H.; Lobach, D.

In: Blood Vessels, Vol. 15, No. 5, 1978, p. 322-330.

Research output: Contribution to journalArticle

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