In vivo wireless ethanol vapor detection in the Wistar rat

C. Parks Cheney, B. Srijanto, D. L. Hedden, A. Gehl, T. L. Ferrell, J. Schultz, E. A. Engleman, W. J. McBride, S. O'Connor

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Traditional alcohol studies measure blood alcohol concentration to elucidate the biomedical factors that contribute to alcohol abuse and alcoholism. These measurements require large and expensive equipment, are labor intensive, and are disruptive to the subject. To alleviate these problems, we have developed an implantable, wireless biosensor that is capable of measuring alcohol levels for up to 6 weeks. Ethanol levels were measured in vivo in the interstitial fluid of a Wistar rat after administering 1 and 2 g/kg ethanol by intraperitoneal (IP) injection. The data were transmitted wirelessly using a biosensor selective for alcohol detection. A low-power piezoresistive microcantilever sensor array was used with a polymer coating suitable for measuring ethanol concentrations at 100 % humidity over several hours. A hydrophobic, vapor permeable nanopore membrane was used to screen liquid and ions while allowing vapor to pass to the sensor from the subcutaneous interstitial fluid.

Original languageEnglish (US)
Pages (from-to)264-269
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume138
Issue number1
DOIs
StatePublished - Apr 24 2009

Keywords

  • Biosensor
  • Ethanol
  • Microcantilevers
  • Piezoresistive

ASJC Scopus subject areas

  • Instrumentation
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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  • Cite this

    Cheney, C. P., Srijanto, B., Hedden, D. L., Gehl, A., Ferrell, T. L., Schultz, J., Engleman, E. A., McBride, W. J., & O'Connor, S. (2009). In vivo wireless ethanol vapor detection in the Wistar rat. Sensors and Actuators, B: Chemical, 138(1), 264-269. https://doi.org/10.1016/j.snb.2009.01.052