Incidence and Outcomes of Malignant Pediatric Lung Neoplasms

Holly L. Neville, Anthony R. Hogan, Ying Zhuge, Eduardo A. Perez, Michael C. Cheung, Leonidas Koniaris, William R. Thompson, Juan E. Sola

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P <0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalJournal of Surgical Research
Volume156
Issue number2
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Lung Neoplasms
Pediatrics
Survival
Incidence
Mucoepidermoid Tumor
Neoplasms
Histology
Lung
Small Cell Carcinoma
Bronchi
Sarcoma
Registries
Early Diagnosis
Squamous Cell Carcinoma
Adenocarcinoma
Therapeutics
Multivariate Analysis
Survival Rate
Population

Keywords

  • lung cancer
  • outcomes
  • pediatric
  • SEER
  • tumor

ASJC Scopus subject areas

  • Surgery

Cite this

Neville, H. L., Hogan, A. R., Zhuge, Y., Perez, E. A., Cheung, M. C., Koniaris, L., ... Sola, J. E. (2009). Incidence and Outcomes of Malignant Pediatric Lung Neoplasms. Journal of Surgical Research, 156(2), 224-230. https://doi.org/10.1016/j.jss.2009.03.100

Incidence and Outcomes of Malignant Pediatric Lung Neoplasms. / Neville, Holly L.; Hogan, Anthony R.; Zhuge, Ying; Perez, Eduardo A.; Cheung, Michael C.; Koniaris, Leonidas; Thompson, William R.; Sola, Juan E.

In: Journal of Surgical Research, Vol. 156, No. 2, 10.2009, p. 224-230.

Research output: Contribution to journalArticle

Neville, HL, Hogan, AR, Zhuge, Y, Perez, EA, Cheung, MC, Koniaris, L, Thompson, WR & Sola, JE 2009, 'Incidence and Outcomes of Malignant Pediatric Lung Neoplasms', Journal of Surgical Research, vol. 156, no. 2, pp. 224-230. https://doi.org/10.1016/j.jss.2009.03.100
Neville, Holly L. ; Hogan, Anthony R. ; Zhuge, Ying ; Perez, Eduardo A. ; Cheung, Michael C. ; Koniaris, Leonidas ; Thompson, William R. ; Sola, Juan E. / Incidence and Outcomes of Malignant Pediatric Lung Neoplasms. In: Journal of Surgical Research. 2009 ; Vol. 156, No. 2. pp. 224-230.
@article{96acf12064284ae8b551bd883d77e878,
title = "Incidence and Outcomes of Malignant Pediatric Lung Neoplasms",
abstract = "Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37{\%}), followed by the upper lobe (31.2{\%}). The most common histology was endocrine tumor (51.6{\%}), followed by sarcoma (11{\%}), and mucoepidermoid tumor (9{\%}). Overall survival was greater than 381 mo with a 15-y survival of 65{\%}. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32{\%}. Surgery improved the 10-y survival to 75{\%} (P <0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.",
keywords = "lung cancer, outcomes, pediatric, SEER, tumor",
author = "Neville, {Holly L.} and Hogan, {Anthony R.} and Ying Zhuge and Perez, {Eduardo A.} and Cheung, {Michael C.} and Leonidas Koniaris and Thompson, {William R.} and Sola, {Juan E.}",
year = "2009",
month = "10",
doi = "10.1016/j.jss.2009.03.100",
language = "English (US)",
volume = "156",
pages = "224--230",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Incidence and Outcomes of Malignant Pediatric Lung Neoplasms

AU - Neville, Holly L.

AU - Hogan, Anthony R.

AU - Zhuge, Ying

AU - Perez, Eduardo A.

AU - Cheung, Michael C.

AU - Koniaris, Leonidas

AU - Thompson, William R.

AU - Sola, Juan E.

PY - 2009/10

Y1 - 2009/10

N2 - Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P <0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.

AB - Background: We sought to define current incidence trends and outcomes for children with lung and bronchus tumors. Methods: The SEER registry was queried from 1973 to 2004 for all patients with pulmonary tumors less than 20 y of age. Results: Overall, 160 patients were identified. The age-adjusted incidence has remained stable at 0.049 per 100,000 persons. The median age at diagnosis was 16 y. Whites had the highest age-adjusted population incidence at 0.056 per 100,000. Most tumors arose in the lower lobe (37%), followed by the upper lobe (31.2%). The most common histology was endocrine tumor (51.6%), followed by sarcoma (11%), and mucoepidermoid tumor (9%). Overall survival was greater than 381 mo with a 15-y survival of 65%. Males had better survival (>381 versus 288 months). Endocrine and mucoepidermoid tumors had the best survival. Small cell carcinoma had the worst median survival at less than 5 mo. Squamous cell carcinoma and adenocarcinoma both had a 14-mo median survival. Median survival for nonsurgically treated patients was 14 mo with a 10-y survival rate of 32%. Surgery improved the 10-y survival to 75% (P <0.0001). Multivariate analysis demonstrated nonsurgical treatment and nonendocrine tumor histology to be independent prognostic factors of death. Conclusion: The incidence of pediatric lung cancer remains stable. Several factors, including nonsurgical treatment and nonendocrine tumors confer a poor prognosis. Early diagnosis and surgical therapy provide the best chance for survival.

KW - lung cancer

KW - outcomes

KW - pediatric

KW - SEER

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=70249107720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249107720&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2009.03.100

DO - 10.1016/j.jss.2009.03.100

M3 - Article

VL - 156

SP - 224

EP - 230

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 2

ER -