Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study

Paul K. Crane, Emily Trittschuh, Shubhabrata Mukherjee, Andrew Saykin, R. Elizabeth Sanders, Eric B. Larson, Susan M. McCurry, Wayne McCormick, James D. Bowen, Thomas Grabowski, Mackenzie Moore, Julianna Bauman, Alden L. Gross, C. Dirk Keene, Thomas D. Bird, Laura E. Gibbons, Jesse Mez

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia. Methods: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments. Results: During 32,286 person-years of follow-up, 869 people developed Alzheimer's dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), visuospatial functioning (117, 14%), language (71, 9%), and executive functioning (66, 8%). The group with isolated relative memory impairments had higher proportions with ≥ APOE ε4 allele, more extensive Alzheimer's-related neuropathology, and higher proportions with other Alzheimer's dementia genetic risk variants. Discussion: A cognitive subgrouping strategy may identify biologically distinct subsets of people with Alzheimer's dementia.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - 2017

Fingerprint

Alzheimer Disease
Cohort Studies
Prospective Studies
Incidence
Language
Alleles
Demography
Neuropathology

Keywords

  • Alzheimer's disease
  • Cognition
  • Endophenotypes
  • Genetics
  • Heterogeneity
  • Neuropathology
  • Subgroups

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. / Crane, Paul K.; Trittschuh, Emily; Mukherjee, Shubhabrata; Saykin, Andrew; Sanders, R. Elizabeth; Larson, Eric B.; McCurry, Susan M.; McCormick, Wayne; Bowen, James D.; Grabowski, Thomas; Moore, Mackenzie; Bauman, Julianna; Gross, Alden L.; Keene, C. Dirk; Bird, Thomas D.; Gibbons, Laura E.; Mez, Jesse.

In: Alzheimer's and Dementia, 2017.

Research output: Contribution to journalArticle

Crane, PK, Trittschuh, E, Mukherjee, S, Saykin, A, Sanders, RE, Larson, EB, McCurry, SM, McCormick, W, Bowen, JD, Grabowski, T, Moore, M, Bauman, J, Gross, AL, Keene, CD, Bird, TD, Gibbons, LE & Mez, J 2017, 'Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2017.04.011
Crane, Paul K. ; Trittschuh, Emily ; Mukherjee, Shubhabrata ; Saykin, Andrew ; Sanders, R. Elizabeth ; Larson, Eric B. ; McCurry, Susan M. ; McCormick, Wayne ; Bowen, James D. ; Grabowski, Thomas ; Moore, Mackenzie ; Bauman, Julianna ; Gross, Alden L. ; Keene, C. Dirk ; Bird, Thomas D. ; Gibbons, Laura E. ; Mez, Jesse. / Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. In: Alzheimer's and Dementia. 2017.
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AU - Sanders, R. Elizabeth

AU - Larson, Eric B.

AU - McCurry, Susan M.

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AU - Bowen, James D.

AU - Grabowski, Thomas

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AU - Bauman, Julianna

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AU - Keene, C. Dirk

AU - Bird, Thomas D.

AU - Gibbons, Laura E.

AU - Mez, Jesse

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N2 - Introduction: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia. Methods: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from a prospective cohort study. We determined individual averages across memory, visuospatial functioning, language, and executive functioning. We identified domains with substantial impairments relative to that average. We compared demographic, neuropathology, and genetic findings across groups defined by relative impairments. Results: During 32,286 person-years of follow-up, 869 people developed Alzheimer's dementia. There were 393 (48%) with no domain with substantial relative impairments. Some participants had isolated relative impairments in memory (148, 18%), visuospatial functioning (117, 14%), language (71, 9%), and executive functioning (66, 8%). The group with isolated relative memory impairments had higher proportions with ≥ APOE ε4 allele, more extensive Alzheimer's-related neuropathology, and higher proportions with other Alzheimer's dementia genetic risk variants. Discussion: A cognitive subgrouping strategy may identify biologically distinct subsets of people with Alzheimer's dementia.

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