Incidence of severe retinopathy of prematurity before and after a modest reduction in target oxygen saturation levels

David K. Wallace, Kathleen A. Veness-Meehan, William C. Miller

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Previous studies suggest that reducing target oxygen saturation levels to 85-93% decreases the incidence of severe retinopathy of prematurity (ROP). Our aim was to determine if a more modest reduction in target oxygen saturation levels also reduces ROP incidence. Methods: One neonatal intensive care unit instituted new oxygen saturation guidelines that changed target levels from the upper 90s to 90-96%. We conducted a retrospective cohort study to determine the proportion of eyes that progressed to (1) threshold or type-1 ROP and (2) stage 3. These proportions were compared between two groups of all eligible infants born up to 10 months before (higher oxygen group, n = 46) and up to 16 months after (lower oxygen group, n = 59) the policy change. Binomial regression was used to calculate relative risks adjusted for birth weight, gestational age, apnea, days of mechanical ventilation, and length of hospital stay. Results: Sixteen of 90 eyes (18%) in the higher oxygen group developed threshold or type-1 ROP versus 16 of 118 eyes (14%) in the lower oxygen group (adjusted relative risk = 0.66, 95% CI = 0.29, 1.51). Twenty-two of 88 eyes (25%) in the higher oxygen group developed stage 3 ROP versus 26 of 118 eyes (22%) in the lower oxygen group (adjusted relative risk = 0.76, 95% CI = 0.43, 1.37). Conclusions: We observed a small but statistically insignificant reduction in the incidence of severe ROP after a modest reduction in target oxygen saturation levels to 90 to 96% in the first several weeks of life.

Original languageEnglish (US)
Pages (from-to)170-174
Number of pages5
JournalJournal of AAPOS
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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Retinopathy of Prematurity
Oxygen
Incidence
Length of Stay
Neonatal Intensive Care Units
Apnea
Artificial Respiration
Birth Weight
Gestational Age
Cohort Studies
Retrospective Studies
Guidelines

ASJC Scopus subject areas

  • Ophthalmology

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Incidence of severe retinopathy of prematurity before and after a modest reduction in target oxygen saturation levels. / Wallace, David K.; Veness-Meehan, Kathleen A.; Miller, William C.

In: Journal of AAPOS, Vol. 11, No. 2, 01.04.2007, p. 170-174.

Research output: Contribution to journalArticle

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