Incidence of urethral involvement in female bladder cancer

An anatomic pathologic study

Shiva Maralani, David P. Wood, David Grignon, Mousumi Banerjee, Wael Sakr, J. Edson Pontes

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objectives. To evaluate risk factors for urethral involvement in female patients undergoing cystectomy for bladder cancer and to define potential candidates for orthotopic continent urinary diversion. Methods. From 1990 to 1996, 43 female patients underwent cystectomy for primary bladder malignancy. Bladder mapping studies were performed with special attention to tumor location multifocality, pathologic stage and grade, presence of carcinoma in situ (CIS), and the relationship of these factors to urethral involvement. Results. Of the 43 patients evaluated, 7 (16.3%) had urethral involvement by tumor. Two patterns of urethral invasion were identified: 5 patients had tumors in the vascular or lymphatic channels of the periurethral tissue, and 2 had rumors in the mucosa or submucosa. Three of the 12 patients with tumors located at the trigone and 4 of the 26 with CIS of the bladder had tumor in the urethra. Three of the 5 patients with vaginal involvement had tumor in the urethra. Only vaginal involvement was significantly associated with urethral involvement (P = 0.02). Conclusions. Vaginal involvement was the only preoperative factor that was associated with presence of tumor in the urethra. Five patients with urethral involvement had submucosal tumors without concomitant CIS of the urethra. Before the performance of orthotopic urinary diversions, intraoperative full-thickness bladder neck biopsies are needed to accurately evaluate the female urethra.

Original languageEnglish (US)
Pages (from-to)537-541
Number of pages5
JournalUrology
Volume50
Issue number4
DOIs
StatePublished - Oct 1997
Externally publishedYes

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Urinary Bladder Neoplasms
Urethra
Incidence
Neoplasms
Carcinoma in Situ
Urinary Diversion
Urinary Bladder
Cystectomy
Blood Vessels
Mucous Membrane
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Incidence of urethral involvement in female bladder cancer : An anatomic pathologic study. / Maralani, Shiva; Wood, David P.; Grignon, David; Banerjee, Mousumi; Sakr, Wael; Pontes, J. Edson.

In: Urology, Vol. 50, No. 4, 10.1997, p. 537-541.

Research output: Contribution to journalArticle

Maralani, Shiva ; Wood, David P. ; Grignon, David ; Banerjee, Mousumi ; Sakr, Wael ; Pontes, J. Edson. / Incidence of urethral involvement in female bladder cancer : An anatomic pathologic study. In: Urology. 1997 ; Vol. 50, No. 4. pp. 537-541.
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abstract = "Objectives. To evaluate risk factors for urethral involvement in female patients undergoing cystectomy for bladder cancer and to define potential candidates for orthotopic continent urinary diversion. Methods. From 1990 to 1996, 43 female patients underwent cystectomy for primary bladder malignancy. Bladder mapping studies were performed with special attention to tumor location multifocality, pathologic stage and grade, presence of carcinoma in situ (CIS), and the relationship of these factors to urethral involvement. Results. Of the 43 patients evaluated, 7 (16.3{\%}) had urethral involvement by tumor. Two patterns of urethral invasion were identified: 5 patients had tumors in the vascular or lymphatic channels of the periurethral tissue, and 2 had rumors in the mucosa or submucosa. Three of the 12 patients with tumors located at the trigone and 4 of the 26 with CIS of the bladder had tumor in the urethra. Three of the 5 patients with vaginal involvement had tumor in the urethra. Only vaginal involvement was significantly associated with urethral involvement (P = 0.02). Conclusions. Vaginal involvement was the only preoperative factor that was associated with presence of tumor in the urethra. Five patients with urethral involvement had submucosal tumors without concomitant CIS of the urethra. Before the performance of orthotopic urinary diversions, intraoperative full-thickness bladder neck biopsies are needed to accurately evaluate the female urethra.",
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