Incomplete recovery of chicken distortion product otoacoustic emissions following acoustic overstimulation

Patricia Trautwein, Richard J. Salvi, Karen Miller, Marlene Shero, Eri Hashino

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Distortion product otoacoustic emissions (DPOAEs) were measured in chickens before and after exposure to a 525-Hz pure tone (120 dB SPL, 48 h). The exposure caused extensive hair cell loss and destroyed the tectorial membrane along the abneural edge of the basilar papilla in the low-to-mid-frequency region of the cochlea. Although the lesion was restricted, DPOAEs were greatly depressed at all frequencies immediately after the exposure. The high-frequency DPOAEs gradually recovered to preexposure values after the exposure; however, there was little or no improvement in DPOAEs at test frequencies equal to or slightly above the exposure frequency even after 16 weeks of recovery. By 28 days of recovery, the previously damaged region of the basilar papilla had been repopulated by hair cells and the lower honeycomb layer of the tectorial membrane had regenerated, but not the upper fibrous layer. The upper fibrous layer of the tectorial membrane was still missing after 16 weeks of recovery and the region of damage corresponded closely to the frequency regions where the DPOAEs were depressed.

Original languageEnglish (US)
Pages (from-to)86-103
Number of pages18
JournalAudiology and Neuro-Otology
Volume1
Issue number2
StatePublished - 1996
Externally publishedYes

Fingerprint

Tectorial Membrane
Acoustics
Organ of Corti
Chickens
Cochlea
Alopecia

Keywords

  • Acoustic trauma
  • Chickens
  • Cochlea
  • Hair cell regeneration
  • Otoacoustic emission
  • Tectorial membrane

ASJC Scopus subject areas

  • Physiology
  • Otorhinolaryngology
  • Neuroscience(all)

Cite this

Incomplete recovery of chicken distortion product otoacoustic emissions following acoustic overstimulation. / Trautwein, Patricia; Salvi, Richard J.; Miller, Karen; Shero, Marlene; Hashino, Eri.

In: Audiology and Neuro-Otology, Vol. 1, No. 2, 1996, p. 86-103.

Research output: Contribution to journalArticle

Trautwein, Patricia ; Salvi, Richard J. ; Miller, Karen ; Shero, Marlene ; Hashino, Eri. / Incomplete recovery of chicken distortion product otoacoustic emissions following acoustic overstimulation. In: Audiology and Neuro-Otology. 1996 ; Vol. 1, No. 2. pp. 86-103.
@article{23439343f47348c4acee7a4e7d32cc0b,
title = "Incomplete recovery of chicken distortion product otoacoustic emissions following acoustic overstimulation",
abstract = "Distortion product otoacoustic emissions (DPOAEs) were measured in chickens before and after exposure to a 525-Hz pure tone (120 dB SPL, 48 h). The exposure caused extensive hair cell loss and destroyed the tectorial membrane along the abneural edge of the basilar papilla in the low-to-mid-frequency region of the cochlea. Although the lesion was restricted, DPOAEs were greatly depressed at all frequencies immediately after the exposure. The high-frequency DPOAEs gradually recovered to preexposure values after the exposure; however, there was little or no improvement in DPOAEs at test frequencies equal to or slightly above the exposure frequency even after 16 weeks of recovery. By 28 days of recovery, the previously damaged region of the basilar papilla had been repopulated by hair cells and the lower honeycomb layer of the tectorial membrane had regenerated, but not the upper fibrous layer. The upper fibrous layer of the tectorial membrane was still missing after 16 weeks of recovery and the region of damage corresponded closely to the frequency regions where the DPOAEs were depressed.",
keywords = "Acoustic trauma, Chickens, Cochlea, Hair cell regeneration, Otoacoustic emission, Tectorial membrane",
author = "Patricia Trautwein and Salvi, {Richard J.} and Karen Miller and Marlene Shero and Eri Hashino",
year = "1996",
language = "English (US)",
volume = "1",
pages = "86--103",
journal = "Audiology and Neuro-Otology",
issn = "1420-3030",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Incomplete recovery of chicken distortion product otoacoustic emissions following acoustic overstimulation

AU - Trautwein, Patricia

AU - Salvi, Richard J.

AU - Miller, Karen

AU - Shero, Marlene

AU - Hashino, Eri

PY - 1996

Y1 - 1996

N2 - Distortion product otoacoustic emissions (DPOAEs) were measured in chickens before and after exposure to a 525-Hz pure tone (120 dB SPL, 48 h). The exposure caused extensive hair cell loss and destroyed the tectorial membrane along the abneural edge of the basilar papilla in the low-to-mid-frequency region of the cochlea. Although the lesion was restricted, DPOAEs were greatly depressed at all frequencies immediately after the exposure. The high-frequency DPOAEs gradually recovered to preexposure values after the exposure; however, there was little or no improvement in DPOAEs at test frequencies equal to or slightly above the exposure frequency even after 16 weeks of recovery. By 28 days of recovery, the previously damaged region of the basilar papilla had been repopulated by hair cells and the lower honeycomb layer of the tectorial membrane had regenerated, but not the upper fibrous layer. The upper fibrous layer of the tectorial membrane was still missing after 16 weeks of recovery and the region of damage corresponded closely to the frequency regions where the DPOAEs were depressed.

AB - Distortion product otoacoustic emissions (DPOAEs) were measured in chickens before and after exposure to a 525-Hz pure tone (120 dB SPL, 48 h). The exposure caused extensive hair cell loss and destroyed the tectorial membrane along the abneural edge of the basilar papilla in the low-to-mid-frequency region of the cochlea. Although the lesion was restricted, DPOAEs were greatly depressed at all frequencies immediately after the exposure. The high-frequency DPOAEs gradually recovered to preexposure values after the exposure; however, there was little or no improvement in DPOAEs at test frequencies equal to or slightly above the exposure frequency even after 16 weeks of recovery. By 28 days of recovery, the previously damaged region of the basilar papilla had been repopulated by hair cells and the lower honeycomb layer of the tectorial membrane had regenerated, but not the upper fibrous layer. The upper fibrous layer of the tectorial membrane was still missing after 16 weeks of recovery and the region of damage corresponded closely to the frequency regions where the DPOAEs were depressed.

KW - Acoustic trauma

KW - Chickens

KW - Cochlea

KW - Hair cell regeneration

KW - Otoacoustic emission

KW - Tectorial membrane

UR - http://www.scopus.com/inward/record.url?scp=0030089950&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030089950&partnerID=8YFLogxK

M3 - Article

C2 - 9390793

AN - SCOPUS:0030089950

VL - 1

SP - 86

EP - 103

JO - Audiology and Neuro-Otology

JF - Audiology and Neuro-Otology

SN - 1420-3030

IS - 2

ER -