Incorrect typing of herpes simplex virus isolates by direct immunofluorescence

Kenneth Fife, Rose Fife, M. B. Kleiman, M. L V French

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The two HSV types are closely related and show substantial antigenic cross-reactivity. This cross-reactivity sometimes makes the results of typing systems that use commercially purchased 'type-specific' polyclonal antibodies difficult to interpret or even incorrect. Reports of specific disease patterns associated with each of the HSV types and reports of differing antiviral susceptibilities make accurate typing of HSV isolates increasingly clinically important. Where a knowledge of the HSV type involved is important, especially in settings where the clinical history differs from the laboratory conclusions, commercial polyclonal antibodies should not be relied upon and typing should be confirmed by an independent method.

Original languageEnglish
Pages (from-to)338
Number of pages1
JournalJournal of Infectious Diseases
Volume148
Issue number2
StatePublished - 1983

Fingerprint

Direct Fluorescent Antibody Technique
Simplexvirus
Antibodies
Antiviral Agents

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Incorrect typing of herpes simplex virus isolates by direct immunofluorescence. / Fife, Kenneth; Fife, Rose; Kleiman, M. B.; French, M. L V.

In: Journal of Infectious Diseases, Vol. 148, No. 2, 1983, p. 338.

Research output: Contribution to journalArticle

@article{63b2f1e762594df1ac737f926b2f6fdc,
title = "Incorrect typing of herpes simplex virus isolates by direct immunofluorescence",
abstract = "The two HSV types are closely related and show substantial antigenic cross-reactivity. This cross-reactivity sometimes makes the results of typing systems that use commercially purchased 'type-specific' polyclonal antibodies difficult to interpret or even incorrect. Reports of specific disease patterns associated with each of the HSV types and reports of differing antiviral susceptibilities make accurate typing of HSV isolates increasingly clinically important. Where a knowledge of the HSV type involved is important, especially in settings where the clinical history differs from the laboratory conclusions, commercial polyclonal antibodies should not be relied upon and typing should be confirmed by an independent method.",
author = "Kenneth Fife and Rose Fife and Kleiman, {M. B.} and French, {M. L V}",
year = "1983",
language = "English",
volume = "148",
pages = "338",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Incorrect typing of herpes simplex virus isolates by direct immunofluorescence

AU - Fife, Kenneth

AU - Fife, Rose

AU - Kleiman, M. B.

AU - French, M. L V

PY - 1983

Y1 - 1983

N2 - The two HSV types are closely related and show substantial antigenic cross-reactivity. This cross-reactivity sometimes makes the results of typing systems that use commercially purchased 'type-specific' polyclonal antibodies difficult to interpret or even incorrect. Reports of specific disease patterns associated with each of the HSV types and reports of differing antiviral susceptibilities make accurate typing of HSV isolates increasingly clinically important. Where a knowledge of the HSV type involved is important, especially in settings where the clinical history differs from the laboratory conclusions, commercial polyclonal antibodies should not be relied upon and typing should be confirmed by an independent method.

AB - The two HSV types are closely related and show substantial antigenic cross-reactivity. This cross-reactivity sometimes makes the results of typing systems that use commercially purchased 'type-specific' polyclonal antibodies difficult to interpret or even incorrect. Reports of specific disease patterns associated with each of the HSV types and reports of differing antiviral susceptibilities make accurate typing of HSV isolates increasingly clinically important. Where a knowledge of the HSV type involved is important, especially in settings where the clinical history differs from the laboratory conclusions, commercial polyclonal antibodies should not be relied upon and typing should be confirmed by an independent method.

UR - http://www.scopus.com/inward/record.url?scp=0020955170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020955170&partnerID=8YFLogxK

M3 - Article

C2 - 6310006

AN - SCOPUS:0020955170

VL - 148

SP - 338

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -