Incorrect typing of herpes simplex virus isolates by direct immunofluorescence

K. H. Fife, R. S. Fife, M. B. Kleiman, M. L.V. French

Research output: Contribution to journalArticle

1 Scopus citations


The two HSV types are closely related and show substantial antigenic cross-reactivity. This cross-reactivity sometimes makes the results of typing systems that use commercially purchased 'type-specific' polyclonal antibodies difficult to interpret or even incorrect. Reports of specific disease patterns associated with each of the HSV types and reports of differing antiviral susceptibilities make accurate typing of HSV isolates increasingly clinically important. Where a knowledge of the HSV type involved is important, especially in settings where the clinical history differs from the laboratory conclusions, commercial polyclonal antibodies should not be relied upon and typing should be confirmed by an independent method.

Original languageEnglish (US)
Number of pages1
JournalJournal of Infectious Diseases
Issue number2
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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