Increase of a nerve growth factor-like protein in the cerebellum of pcd mutant mice

J. P. Schwartz, Bernardino Ghetti, L. Truex, M. J. Schmidt

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Several areas of mouse brain (cerebellum, brain stem, and hemispheres) contain levels of nerve growth factor (NGF) detectable by radioimmunoassay. However, this immunoactive NGF is not biologically active in the chick embryo sensory ganglia bioassay. Cerebellum from pcd mice, in which neuronal degeneration elicits a glial response, contains increased amounts of NGF immunoactivity. These results suggest that CNS glia may produce a NGF-like protein for CNS neurons.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalJournal of Neuroscience Research
Volume8
Issue number2-3
StatePublished - 1982

Fingerprint

Nerve Growth Factor
Cerebellum
Neuroglia
Proteins
Sensory Ganglia
Chick Embryo
Biological Assay
Brain Stem
Radioimmunoassay
Neurons
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Increase of a nerve growth factor-like protein in the cerebellum of pcd mutant mice. / Schwartz, J. P.; Ghetti, Bernardino; Truex, L.; Schmidt, M. J.

In: Journal of Neuroscience Research, Vol. 8, No. 2-3, 1982, p. 205-211.

Research output: Contribution to journalArticle

Schwartz, J. P. ; Ghetti, Bernardino ; Truex, L. ; Schmidt, M. J. / Increase of a nerve growth factor-like protein in the cerebellum of pcd mutant mice. In: Journal of Neuroscience Research. 1982 ; Vol. 8, No. 2-3. pp. 205-211.
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