Increase of a nerve growth factor‐like protein in the cerebellum of PCD mutant mice

Joan P. Schwartz, Bernardino Ghetti, Lewis Truex, Michael J. Schmidt

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Several areas of mouse brain (cerebellum, brain stem, and hemispheres) contain levels of nerve growth factor (NGF) detectable by radioimmunoassay. However, this immunoactive NGF is not biologically active in the chick embryo sensory ganglia bioassay. Cerebellum from pcd mice, in which neuronal degeneration elicits a glial response, contains increased amounts of NGF immunoactivity. These results suggest that CNS glia may produce a NGF-like protein for CNS neurons.

Original languageEnglish (US)
Pages (from-to)205-211
Number of pages7
JournalJournal of Neuroscience Research
Volume8
Issue number2-3
DOIs
StatePublished - 1982

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Keywords

  • cerebellum
  • glia
  • nerve growth factor
  • neuronal degeneration

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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