Increased abundance of na,k-atpase dl and bl s u b units in kidneys from rats subjected to chronic k depletion

Yel Minyhao Yel, Robert Bacallao, Frank A. Carone, Sakia Nakamura, Daniel Batllel

Research output: Contribution to journalArticle

Abstract

K depletion leads to an increase in functional Na,K-ATPase activity in kidney homogen at es, microdissected medullary collecting tubules and cultured renal cells. This increase would be maladaptive in terms of renal K conservation unless if the increase in enzyme activity reflected, at least in part, sorting to the apical as opposed to the basolateral membrane. We have shown, by immunohistochemistry, that there is apical expression of Na,K-ATPase dl subunit in renal collecting tubules from rats with K depletion ( J Invest Med 1995;43:353A). The present study was undertaken to characterize Na,K-ATPase subunits expression during chronic K depletion. Rats were sacrificed after being fed a low potassium diet for 4-6 weeks ( plasma K 2. 6±0. 18 vs 4. 1+0. 13 mEq/L in pair fed controls P

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume44
Issue number3
StatePublished - 1996
Externally publishedYes

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Adenosine Triphosphatases
Rats
Kidney
Enzyme activity
Nutrition
Sorting
Conservation
Potassium
Membranes
Plasmas
Cultured Cells
Immunohistochemistry
Diet
sodium-translocating ATPase
Enzymes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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Increased abundance of na,k-atpase dl and bl s u b units in kidneys from rats subjected to chronic k depletion. / Minyhao Yel, Yel; Bacallao, Robert; Carone, Frank A.; Nakamura, Sakia; Batllel, Daniel.

In: Journal of Investigative Medicine, Vol. 44, No. 3, 1996.

Research output: Contribution to journalArticle

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AU - Batllel, Daniel

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