Increased adolescent opioid use and complications reported to a poison control center following the 2000 JCAHO pain initiative

Laura M. Tormoehlen, James B. Mowry, Jeffrey D. Bodle, Daniel Rusyniak

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Context. Adolescents are at risk to abuse opioid analgesics for many reasons, including inaccurate perception of risk and increased drug availability. In 2000, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) released pain management standards that emphasized pain control as a patient rights issue. This focus on analgesia may have increased both the prescribing and use of opioid analgesics, thereby increasing availability. Objective. Using data from a US poison center, this study aims to compare the number of adolescent opioid cases and their outcome severity before and after the 2000 JCAHO pain initiative. Methods. Retrospective case series of opioid exposures involving persons 1218 years of age reported to a US poison center from 1994 to 2007. The main outcome measure was the number of adolescent opioid cases reported for 19942000 compared to 20012007. Secondary outcomes included outcome severity, number of cases involving specific opioids, and correlation between the number of cases and the amount of opioids distributed to the state. Results. There were 1634 adolescent opioid-related cases with 187 cases developing medical complications. Compared with 19942000, the rate ratio of cases involving adolescents and opioid analgesics for the years 20012007 was 1.69 (95% CI: 1.53, 1.86), and these cases were 2.84 (95% CI: 2.06, 3.91) times more likely to have had medical complications. Medical complications involving methadone (p =0.001) increased after the JCAHO initiative, while complications related to codeine (p =0.001) and propoxyphene (p =0.030) decreased. There were 15 deaths in 20012007 and none in 19942000 (p =0.012). Lastly, there was a correlation between the rate of adolescent opioid cases and the amount of opioids distributed to the state (r 2 =0.90; p < 0.001). Conclusion. In the 7 years following the JCAHO pain standards, there was an increase in the number and severity of adolescent opioid-related poison center cases. The increase correlates with statewide availability of opioids. These data may prove useful in drug education and prevention programs targeting adolescents.

Original languageEnglish
Pages (from-to)492-498
Number of pages7
JournalClinical Toxicology
Volume49
Issue number6
DOIs
StatePublished - Jul 2011

Fingerprint

Poison Control Centers
Joint Commission on Accreditation of Healthcare Organizations
Accreditation
Poisons
Opioid Analgesics
Pain
Availability
Dextropropoxyphene
Codeine
Methadone
Patient Rights
Pain Management
Pharmaceutical Preparations

Keywords

  • Opioids
  • Prescription drugs
  • Substance-related disorders

ASJC Scopus subject areas

  • Toxicology

Cite this

Increased adolescent opioid use and complications reported to a poison control center following the 2000 JCAHO pain initiative. / Tormoehlen, Laura M.; Mowry, James B.; Bodle, Jeffrey D.; Rusyniak, Daniel.

In: Clinical Toxicology, Vol. 49, No. 6, 07.2011, p. 492-498.

Research output: Contribution to journalArticle

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abstract = "Context. Adolescents are at risk to abuse opioid analgesics for many reasons, including inaccurate perception of risk and increased drug availability. In 2000, the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) released pain management standards that emphasized pain control as a patient rights issue. This focus on analgesia may have increased both the prescribing and use of opioid analgesics, thereby increasing availability. Objective. Using data from a US poison center, this study aims to compare the number of adolescent opioid cases and their outcome severity before and after the 2000 JCAHO pain initiative. Methods. Retrospective case series of opioid exposures involving persons 1218 years of age reported to a US poison center from 1994 to 2007. The main outcome measure was the number of adolescent opioid cases reported for 19942000 compared to 20012007. Secondary outcomes included outcome severity, number of cases involving specific opioids, and correlation between the number of cases and the amount of opioids distributed to the state. Results. There were 1634 adolescent opioid-related cases with 187 cases developing medical complications. Compared with 19942000, the rate ratio of cases involving adolescents and opioid analgesics for the years 20012007 was 1.69 (95{\%} CI: 1.53, 1.86), and these cases were 2.84 (95{\%} CI: 2.06, 3.91) times more likely to have had medical complications. Medical complications involving methadone (p =0.001) increased after the JCAHO initiative, while complications related to codeine (p =0.001) and propoxyphene (p =0.030) decreased. There were 15 deaths in 20012007 and none in 19942000 (p =0.012). Lastly, there was a correlation between the rate of adolescent opioid cases and the amount of opioids distributed to the state (r 2 =0.90; p < 0.001). Conclusion. In the 7 years following the JCAHO pain standards, there was an increase in the number and severity of adolescent opioid-related poison center cases. The increase correlates with statewide availability of opioids. These data may prove useful in drug education and prevention programs targeting adolescents.",
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