Increased brain activation during working memory processing after pediatric mild traumatic brain injury (mTBI)

Daniel R. Westfall, John D. West, Jessica N. Bailey, Todd W. Arnold, Patrick A. Kersey, Andrew Saykin, Brenna McDonald

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

PURPOSE: The neural substrate of post-concussive symptoms following the initial injury period after mild traumatic brain injury (mTBI) in pediatric populations remains poorly elucidated. This study examined neuropsychological, behavioral, and brain functioning in adolescents post-mTBI to assess whether persistent differences were detectable up to a year post-injury. METHODS: Nineteen adolescents on average 7.5 months post-mTBI completed neuropsychological testing and an fMRI auditory-verbal N-back working memory task. Parents completed behavioral ratings. The comparison group included 19 healthy controls matched to the mTBI group for demographic variables and N-back task performance. RESULTS: There were no between-group differences for cognition or behavior ratings. The expected decreased accuracy and increased reaction time as N-back task difficulty increased were apparent. The mTBI group showed significantly greater brain activation than controls during the most difficult working memory load condition. CONCLUSION: Greater working memory task-related activation was found in adolescents up to one year post-mTBI relative to controls, potentially indicating compensatory activation to support normal task performance. Differences in brain activation in the mTBI group so long after injury may indicate residual alterations in brain function much later than would be expected based on the typical pattern of symptom recovery, which could have important clinical implications.

Original languageEnglish (US)
Pages (from-to)297-308
Number of pages12
JournalJournal of Pediatric Rehabilitation Medicine
Volume8
Issue number4
DOIs
StatePublished - Nov 13 2015

Fingerprint

Brain Concussion
Short-Term Memory
Pediatrics
Brain
Task Performance and Analysis
Wounds and Injuries
Post-Concussion Syndrome
Cognition
Reaction Time
Parents
Magnetic Resonance Imaging
Demography

Keywords

  • Concussion
  • fMRI
  • functional magnetic resonance imaging
  • mild traumatic brain injury
  • mTBI
  • pediatric
  • working memory

ASJC Scopus subject areas

  • Rehabilitation
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Pediatrics, Perinatology, and Child Health

Cite this

Increased brain activation during working memory processing after pediatric mild traumatic brain injury (mTBI). / Westfall, Daniel R.; West, John D.; Bailey, Jessica N.; Arnold, Todd W.; Kersey, Patrick A.; Saykin, Andrew; McDonald, Brenna.

In: Journal of Pediatric Rehabilitation Medicine, Vol. 8, No. 4, 13.11.2015, p. 297-308.

Research output: Contribution to journalArticle

Westfall, Daniel R. ; West, John D. ; Bailey, Jessica N. ; Arnold, Todd W. ; Kersey, Patrick A. ; Saykin, Andrew ; McDonald, Brenna. / Increased brain activation during working memory processing after pediatric mild traumatic brain injury (mTBI). In: Journal of Pediatric Rehabilitation Medicine. 2015 ; Vol. 8, No. 4. pp. 297-308.
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