Increased cyclin D1 expression in chronic pancreatitis

Marko Kornmann, Toshiyuki Ishiwata, Nadir Arber, Hans G. Beger, Murray Korc

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Cyclin D1 is an important regulator of the G1 phase of the cell cycle. In this study we examined the expression and localization of cyclin D1 in chronic pancreatitis (CP), a condition associated with fibrosis, acinar cell degeneration, and foci of duct cell proliferation. Northern blotting of total RNA from the normal pancreas and from the pancreas of patients with CP revealed the presence of 4.4-kb cyclin D1 mRNA transcript in all samples. Densitometric analysis indicated that pancreatic cyclin D1 mRNA levels were 2.0-fold increased in CP compared to normal controls (p = 0.0046). In the normal pancreas, faint cyclin D1 immunoreactivity was present in the nuclei and cytoplasm of some ductal cells and islet cell. In contrast, in CO, moderate to strong cyclin D1 immunoreactivity was present in many ductal and islet cells, as well as in some acinar cells and fibroblasts. These findings rase the possibility that enhanced cyclin D1 expression may contribute to a hyperproliferative state in CP.

Original languageEnglish (US)
Pages (from-to)158-162
Number of pages5
JournalPancreas
Volume17
Issue number2
DOIs
StatePublished - Aug 1998

Keywords

  • Chronic pancreatitis
  • Cyclin D1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Fingerprint Dive into the research topics of 'Increased cyclin D1 expression in chronic pancreatitis'. Together they form a unique fingerprint.

  • Cite this

    Kornmann, M., Ishiwata, T., Arber, N., Beger, H. G., & Korc, M. (1998). Increased cyclin D1 expression in chronic pancreatitis. Pancreas, 17(2), 158-162. https://doi.org/10.1097/00006676-199808000-00008