Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival

Marko Kornmann, Toshiyuki Ishiwata, Jun Itakura, Pam Tangvoranuntakul, Hans G. Beger, Murray Korc

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Cyclin D1 belongs to a family of protein kinases that have been implicated in cell cycle regulation. In the present study we characterized cyclin D1 expression in 6 cultured human pancreatic cancer cell lines and in normal and cancerous human pancreatic tissues. A 4.4-kb cyclin D1 mRNA transcript was present in all cell lines and in all pancreatic tissues. Cyclin D1 mRNA levels were 2.1-fold higher in the pancreatic cancers than in normal pancreatic tissues (p < 0.0002). Cancer patients with lower cyclin D1 levels (n = 16) had a median survival of 15.5 months whereas patients with higher levels (n = 16) had a median survival of 6.5 months (p < 0.007). These data indicate that cyclin D1 expression may serve as a predictor of postoperative survival in pancreatic cancer patients, and raise the possibility that treatment modalities blocking cyclin D1 activity may have a future role in the therapy of these patients.

Original languageEnglish (US)
Pages (from-to)363-369
Number of pages7
JournalONCOLOGY
Volume55
Issue number4
DOIs
StatePublished - Jul 1 1998

Keywords

  • Cyclin D1
  • Pancreatic cancer
  • Prognostic parameter

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kornmann, M., Ishiwata, T., Itakura, J., Tangvoranuntakul, P., Beger, H. G., & Korc, M. (1998). Increased cyclin D1 in human pancreatic cancer is associated with decreased postoperative survival. ONCOLOGY, 55(4), 363-369. https://doi.org/10.1159/000011879