Increased energy expenditure in infants with cyanotic congenital heart disease

C. A. Leitch, C. A. Karn, R. J. Peppard, D. Granger, E. A. Liechty, G. J. Ensing, S. C. Denne

Research output: Contribution to journalArticle

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Abstract

Infants with cyanotic congenital heart disease (CCHD) often have reduced weight gain compared with infants in control groups. Our purpose was to conduct a longitudinal study of energy intake, resting energy expenditure (REE), and total energy expenditure (TEE) of a group of infants with CCHD. We hypothesized that increased REE and TEE and decreased energy intake in these infants would lead to reduced growth. Ten infants with uncorrected CCHD and 12 infants in a control group were studied at 2 weeks of age and again at 3 months. Indirect calorimetry was used to determine REE; the doubly labeled water method was used to determine TEE and intake. At 2 weeks and 3 months of age, infants with CCHD weighed significantly less than infants in the control group. No significant difference was seen in energy intake or REE between groups during either period. TEE was slightly but not statistically increased in the CCHD group at 2 weeks (72.6 ± 17.4 vs 59.8 ± 10.9 kcal/kg/d) and significantly increased at 5 months (93.6 ± 23.3 vs 72.2 ± 13.2 kcal/kg/d, P ≤ .03). We conclude that increased TEE but not increased REE is a primary factor in the reduced growth in infants with CCHD.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalJournal of Pediatrics
Volume133
Issue number6
DOIs
StatePublished - Jan 1 1998

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Energy Metabolism
Heart Diseases
Energy Intake
Control Groups
Indirect Calorimetry
Growth
Weight Gain
Longitudinal Studies
Water

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Leitch, C. A., Karn, C. A., Peppard, R. J., Granger, D., Liechty, E. A., Ensing, G. J., & Denne, S. C. (1998). Increased energy expenditure in infants with cyanotic congenital heart disease. Journal of Pediatrics, 133(6), 755-760. https://doi.org/10.1016/S0022-3476(98)70146-5

Increased energy expenditure in infants with cyanotic congenital heart disease. / Leitch, C. A.; Karn, C. A.; Peppard, R. J.; Granger, D.; Liechty, E. A.; Ensing, G. J.; Denne, S. C.

In: Journal of Pediatrics, Vol. 133, No. 6, 01.01.1998, p. 755-760.

Research output: Contribution to journalArticle

Leitch, CA, Karn, CA, Peppard, RJ, Granger, D, Liechty, EA, Ensing, GJ & Denne, SC 1998, 'Increased energy expenditure in infants with cyanotic congenital heart disease', Journal of Pediatrics, vol. 133, no. 6, pp. 755-760. https://doi.org/10.1016/S0022-3476(98)70146-5
Leitch CA, Karn CA, Peppard RJ, Granger D, Liechty EA, Ensing GJ et al. Increased energy expenditure in infants with cyanotic congenital heart disease. Journal of Pediatrics. 1998 Jan 1;133(6):755-760. https://doi.org/10.1016/S0022-3476(98)70146-5
Leitch, C. A. ; Karn, C. A. ; Peppard, R. J. ; Granger, D. ; Liechty, E. A. ; Ensing, G. J. ; Denne, S. C. / Increased energy expenditure in infants with cyanotic congenital heart disease. In: Journal of Pediatrics. 1998 ; Vol. 133, No. 6. pp. 755-760.
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