Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls, Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.
- Human heart failure
- Protein phosphorylation
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine