Increased expression of cardiac phosphatases in patients with end-stage heart failure

Joachim Neumann, Thomas Eschenhagen, Larry R. Jones, Bettina Linck, Wilhelm Schmitz, Hasso Scholz, Norbert Zimmermann

Research output: Contribution to journalArticle

201 Scopus citations

Abstract

Type 1 phosphatase activity was increased in membrane vesicles from failing human ventricles compared with non-failing controls, Likewise, expression of the mRNA encoding for type 1 phosphatase was enhanced by 37%. The present study provides evidence that alterations of phosphatase activity coincide with end-stage heart failure. Thus, enhanced activity of phosphatases may be causally related to heart failure and/or may aggravate the well known decreased cardiac responsiveness to positive inotropic agents in end-stage heart failure.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume29
Issue number1
DOIs
StatePublished - Jan 1997

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Keywords

  • Human heart failure
  • Phosphatases
  • Protein phosphorylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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